Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Sci Immunol. 2022 Apr;7(70):eabm9409. doi: 10.1126/sciimmunol.abm9409. Epub 2022 Apr 1.
Dendritic cells (DCs) are professional antigen-presenting cells, orchestrating innate and adaptive immunity during infections, autoimmune diseases, and malignancies. Since the discovery of DCs almost 50 years ago, our understanding of their biology in humans has increased substantially. Here, we review both antitumor and tolerogenic DC responses in cancer and discuss lineage-specific contributions by their functionally specialized subsets, including the conventional DC (cDC) subsets cDC1 and cDC2, the newly described DC3, and the plasmacytoid DCs (pDCs), focusing on the human setting. In addition, we review the lineage-unrestricted "mature DCs enriched in immunoregulatory molecules" (mregDC) state recently described across different human tumors.
树突状细胞（DCs）是专业的抗原呈递细胞，在感染、自身免疫性疾病和恶性肿瘤中协调先天和适应性免疫。自 50 年前发现 DCs 以来，我们对人类中它们的生物学特性的理解已经大大增加。在这里，我们回顾了癌症中的抗肿瘤和耐受原性 DC 反应，并讨论了其功能特化亚群的谱系特异性贡献，包括传统 DC（cDC）亚群 cDC1 和 cDC2、新描述的 DC3 和浆细胞样 DC（pDCs），重点是人类环境。此外，我们还回顾了最近在不同人类肿瘤中描述的谱系无限制的“富含免疫调节分子的成熟 DCs”（mregDC）状态。
