Hu Xiaopeng, Jiang Chunmei, Gao Yang, Xue Xingkui
Medical Research Center, People's Hospital of Longhua, The Affiliated Hospital of Southern Medical University, Shenzhen 518000, China; Biosafety Level-3 Laboratory, Life Sciences Institute & Guangxi Collaborative Innovation Center for Biomedicine, Guangxi Medical University, Nanning 530021, China.
Medical Research Center, People's Hospital of Longhua, The Affiliated Hospital of Southern Medical University, Shenzhen 518000, China.
J Neuroimmunol. 2023 Oct 15;383:578147. doi: 10.1016/j.jneuroim.2023.578147. Epub 2023 Jul 10.
Glioblastoma (GBM) is the most aggressive type of glioma (Grade IV). The presence of cytotoxic T lymphocyte (CTLs) has been associated with improved outcomes in patients with GBM, and it is believed that the activation of CTLs by dendritic cells may play a critical role in controlling the growth of GBM. DCs are professional antigen-presenting cells (APC) that orchestrate innate and adaptive anti-GBM immunity. DCs can subsequently differentiate into plasmacytoid DCs (pDC), conventional DC1 (cDC1), conventional (cDC2), and monocyte-derived DCs (moDC) depending on environmental exposure. The different subsets of DCs exhibit varying functional capabilities in antigen presentation and T cell activation in producing an antitumor response. In this review, we focus on recent studies describing the phenotypic and functional characteristics of DC subsets in humans and their respective antitumor immunity and immunotolerance roles in the GBM-associated microenvironment. The critical components of crosstalk between DC subsets that contribute significantly to GBM-specific immune responses are also highlighted in this review with reference to the latest literature. Since DCs could be prime targets for therapeutic intervention, it is worth summarizing the relevance of DC subsets with respect to GBM-associated immunologic tolerance and their therapeutic potential.
胶质母细胞瘤（GBM）是最具侵袭性的胶质瘤类型（IV级）。细胞毒性T淋巴细胞（CTL）的存在与GBM患者预后改善相关，并且人们认为树突状细胞对CTL的激活可能在控制GBM生长中起关键作用。树突状细胞是专业的抗原呈递细胞（APC），可协调先天性和适应性抗GBM免疫。随后，树突状细胞可根据环境暴露情况分化为浆细胞样树突状细胞（pDC）、常规树突状细胞1（cDC1）、常规树突状细胞（cDC2）和单核细胞衍生树突状细胞（moDC）。不同亚群的树突状细胞在抗原呈递和T细胞激活以产生抗肿瘤反应方面表现出不同的功能能力。在这篇综述中，我们重点关注最近描述人类树突状细胞亚群的表型和功能特征及其在GBM相关微环境中各自的抗肿瘤免疫和免疫耐受作用的研究。本文还参考最新文献，强调了对GBM特异性免疫反应有显著贡献的树突状细胞亚群之间相互作用的关键组成部分。由于树突状细胞可能是治疗干预的主要靶点，因此有必要总结树突状细胞亚群与GBM相关免疫耐受的相关性及其治疗潜力。
