Katsnelson B A, Polzik E V, Privalova L I
Environ Health Perspect. 1986 Sep;68:175-85. doi: 10.1289/ehp.8668175.
Based on experimental and epidemiological data findings presented here, as well as on data of other investigators, the authors conclude that a wide interindividual variability of susceptibility to silicosis is a real phenomenon. This susceptibility depends on both intrinsic features of the host and the influence of many environmental factors. The effect of any such factor is realized at different stages of silicosis pathogenesis and in close interrelation with the influence of other factors. The necessity of multifactorial analysis is stressed, and an example of such analysis is presented.
基于此处呈现的实验和流行病学数据结果,以及其他研究者的数据,作者得出结论:个体对矽肺易感性的广泛差异是一个真实存在的现象。这种易感性既取决于宿主的内在特征,也受许多环境因素的影响。任何此类因素的作用在矽肺发病机制的不同阶段得以体现,且与其他因素的影响密切相关。强调了多因素分析的必要性,并给出了一个此类分析的示例。