Flicoteaux H, Kher A, Jean N, Blery M, Judet T, Honnart F, Pasteyer J
Pathol Biol (Paris). 1977 Dec;25 Suppl:55-8.
In a prospective randomised trial, two groups of 20 patients each were compared. The first group received low dose heparin (t.i.d.) and the second group received low dose heparin (t.i.d.) combined with aspirin. The incidence of deep vein thrombosis (DVT) were determined using both radioactive fibrinogen uptake test and venography. The correlation between the two methods of diagnosis was better than 90%. There was no significant difference in the incidence of DVT between the two prophylactic regimen. A significant tendancy towards increased bleeding in observed with the combination of low dose heparin and aspirin.
在一项前瞻性随机试验中，对两组各20名患者进行了比较。第一组接受低剂量肝素（每日三次），第二组接受低剂量肝素（每日三次）联合阿司匹林。使用放射性纤维蛋白原摄取试验和静脉造影术来确定深静脉血栓形成（DVT）的发生率。两种诊断方法之间的相关性优于90%。两种预防方案之间DVT的发生率没有显著差异。观察到低剂量肝素和阿司匹林联合使用时有出血增加的显著趋势。
