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Frequency of the PNPLA3 rs738409 polymorphism and other genetic loci for liver disease in a Guatemalan adult population.危地马拉成年人群中PNPLA3 rs738409多态性及其他肝脏疾病相关基因位点的频率
Liver Int. 2022 Jun;42(6):1470-1474. doi: 10.1111/liv.15268. Epub 2022 Apr 12.
2
Associations of PNPLA3 rs738409 Polymorphism with Plasma Lipid Levels: A Systematic Review and Meta-Analysis.PNPLA3 rs738409多态性与血脂水平的关联：一项系统评价和荟萃分析
Horm Metab Res. 2022 Oct;54(10):686-695. doi: 10.1055/a-1929-1677. Epub 2022 Oct 7.
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African genetic ancestry is associated with lower frequency of PNPLA3 G allele in non-alcoholic fatty liver in an admixed population.非洲遗传血统与混合人群中非酒精性脂肪性肝病中 PNPLA3 G 等位基因的低频率相关。
Ann Hepatol. 2022 Nov-Dec;27(6):100728. doi: 10.1016/j.aohep.2022.100728. Epub 2022 Jun 13.
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Effects of PNPLA3, TM6SF2 and SAMM50 on the development and severity of non-alcoholic fatty liver disease in children.载脂蛋白 PLA3、TM6SF2 和 SAMM50 对儿童非酒精性脂肪性肝病的发生发展及严重程度的影响。
Pediatr Obes. 2022 Feb;17(2):e12852. doi: 10.1111/ijpo.12852. Epub 2021 Sep 7.
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The Risk of Cirrhosis and Its Complications Based on PNPLA3 rs738409 G Allele Frequency.基于 PNPLA3 rs738409 G 等位基因频率的肝硬化及其并发症风险。
Dig Dis. 2022;40(5):625-634. doi: 10.1159/000521062. Epub 2021 Nov 22.
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Association of rs738409 Polymorphism in Adiponutrin Gene with Liver Steatosis and Atherosclerosis Risk Factors in Greek Children and Adolescents.载脂蛋白脂肪酶基因 rs738409 多态性与希腊儿童和青少年肝脂肪变性及动脉粥样硬化危险因素的关系。
Nutrients. 2022 Aug 23;14(17):3452. doi: 10.3390/nu14173452.
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The variability of PNPLA3 gene as a potential marker of cold adaptation in Yakuts.PNPLA3 基因的变异性作为雅库特人冷适应的潜在标志物。
Int J Circumpolar Health. 2023 Dec;82(1):2246647. doi: 10.1080/22423982.2023.2246647.
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A PNPLA3 Polymorphism Confers Lower Susceptibility to Incident Diabetes Mellitus in Subjects With Nonalcoholic Fatty Liver Disease.载脂蛋白 L3 多态性降低非酒精性脂肪性肝病患者发生糖尿病的易感性。
Clin Gastroenterol Hepatol. 2022 Mar;20(3):682-691.e8. doi: 10.1016/j.cgh.2021.04.038. Epub 2021 Apr 24.
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PNPLA3 GENE POLYMORPHISM AND RED MEAT CONSUMPTION INCREASED FIBROSIS RISK IN NASH BIOPSY-PROVEN PATIENTS UNDER MEDICAL FOLLOW-UP IN A TERTIARY CENTER IN SOUTHWEST BRAZIL.在巴西西南部一家三级中心接受医学随访的经活检证实的非酒精性脂肪性肝炎（NASH）患者中，PNPLA3基因多态性和红肉消费增加了肝纤维化风险。
Arq Gastroenterol. 2023 Jan-Mar;60(1):98-105. doi: 10.1590/S0004-2803.202301000-13.

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Polygenic Risk Score for Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis: A Narrative Review.代谢功能障碍相关脂肪性肝病和脂肪性肝炎的多基因风险评分：一项叙述性综述。
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Cureus. 2024 Oct 17;16(10):e71730. doi: 10.7759/cureus.71730. eCollection 2024 Oct.
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Global Epidemiological Impact of PNPLA3 I148M on Liver Disease.PNPLA3 I148M对肝脏疾病的全球流行病学影响。
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Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches.探讨遗传变异在非酒精性脂肪性肝病中的作用：对疾病发病机制和精准医学方法的启示。
Eur J Med Res. 2024 Mar 20;29(1):190. doi: 10.1186/s40001-024-01708-8.

本文引用的文献

1
Racial and ethnic disparities in non-alcoholic fatty liver disease in the USA.美国非酒精性脂肪性肝病中的种族和民族差异。
Lancet Gastroenterol Hepatol. 2021 Jun;6(6):422-424. doi: 10.1016/S2468-1253(21)00100-X.
2
Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis.载脂蛋白 PNPLA3 在脂滴上的积累是相关肝脂肪变性的基础。
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9521-9526. doi: 10.1073/pnas.1901974116. Epub 2019 Apr 24.
3
Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) susceptibility and severity: A meta-analysis.PNPLA3基因rs738409多态性与非酒精性脂肪性肝病（NAFLD）易感性及严重程度的关联：一项荟萃分析。
Medicine (Baltimore). 2019 Feb;98(7):e14324. doi: 10.1097/MD.0000000000014324.
4
High prevalence of non-alcoholic fatty liver disease and metabolic risk factors in Guatemala: A population-based study.危地马拉非酒精性脂肪性肝病及代谢风险因素的高患病率：一项基于人群的研究。
Nutr Metab Cardiovasc Dis. 2019 Feb;29(2):191-200. doi: 10.1016/j.numecd.2018.10.008. Epub 2018 Oct 31.
5
Contribution of PNPLA3 gene to the natural history of liver diseases.PNPLA3基因对肝脏疾病自然史的影响。
Acta Gastroenterol Belg. 2017 Jan-Mar;80(1):43-51.
6
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.全球非酒精性脂肪性肝病流行病学——患病率、发病率和结局的荟萃分析评估。
Hepatology. 2016 Jul;64(1):73-84. doi: 10.1002/hep.28431. Epub 2016 Feb 22.
7
Association between variants in or near PNPLA3, GCKR, and PPP1R3B with ultrasound-defined steatosis based on data from the third National Health and Nutrition Examination Survey.基于第三次国家健康与营养调查数据，探讨 PNPLA3、GCKR 和 PPP1R3B 基因内或附近变异与超声定义的脂肪变性之间的关系。
Clin Gastroenterol Hepatol. 2013 Sep;11(9):1183-1190.e2. doi: 10.1016/j.cgh.2013.02.011. Epub 2013 Feb 13.
8
PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.PNPLA3 变异体特异性增加肝组织学非酒精性脂肪性肝病的风险，但不增加代谢疾病的风险。
Hepatology. 2010 Sep;52(3):904-12. doi: 10.1002/hep.23768.
9
What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.相对风险是什么？一种在常见结局队列研究中校正优势比的方法。
JAMA. 1998 Nov 18;280(19):1690-1. doi: 10.1001/jama.280.19.1690.

Frequency of the PNPLA3 rs738409 polymorphism and other genetic loci for liver disease in a Guatemalan adult population.

作者信息

Lazo Mariana, Xie Jiaqi, Alvarez Christian S, Parisi Dominick, Yang Stephanie, Rivera-Andrade Alvaro, Kroker-Lobos Maria F, Groopman John D, Guallar Eliseo, Ramirez-Zea Manuel, Arking Dan E, McGlynn Katherine A

机构信息

Department of Community Health and Prevention, Drexel Dornsife School of Public Health, Philadelphia, Pennsylvania, USA.

Urban Health Collaborative, Drexel Dornsife School of Public Health, Philadelphia, Pennsylvania, USA.

出版信息

Liver Int. 2022 Jun;42(6):1470-1474. doi: 10.1111/liv.15268. Epub 2022 Apr 12.

DOI:10.1111/liv.15268
PMID:35365950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9241623/
Abstract
摘要