University of Turku, Turku, Finland.
Centre for Population Health Research, Turku University Hospital, University of Turku, Turku, Finland.
Acta Paediatr. 2022 Aug;111(8):1603-1611. doi: 10.1111/apa.16349. Epub 2022 Apr 6.
We studied whether repeatedly measured weight gain from birth up to age 2 years associated with cardiometabolic health in young adulthood.
Using the data collected in the longitudinal Special Turku Coronary Risk Factor Intervention Project, we investigated in 454 healthy subjects how early weight gain in six age intervals (birth to 7 months, 7-13 months, 13-18 months, 18-24 months, and birth to 13 and 24 months) associated with measures of cardiometabolic health at age 20 years. Linear regression analyses were controlled for (1) child's sex, intervention/control group, gestational age, baseline weight and change in length for each interval, and (2) parents' education, mother's weight before pregnancy, height and weight gain during pregnancy, and father's body mass index at the 7-month visit.
Weight gain after the first year of life associated directly, when adjusted for traits of the child and parents, with systolic blood pressure, waist circumference and body mass index at age 20 years. In the fully adjusted analyses, weight gain from birth to 1 year and to 2 years of age associated inversely with insulin and insulin resistance. We found no association between early growth and diastolic blood pressure or serum lipids.
Early weight gain during first 2 years of life may predict later markers of cardiometabolic health.
我们研究了从出生到 2 岁期间反复测量的体重增加与年轻人的心血管代谢健康之间的关系。
我们使用纵向特殊图尔库冠状动脉风险因素干预研究中收集的数据，在 454 名健康受试者中研究了六个年龄间隔（出生到 7 个月、7-13 个月、13-18 个月、18-24 个月和出生到 13 个月和 24 个月）内的早期体重增加与 20 岁时心血管代谢健康测量值之间的关系。线性回归分析控制了（1）儿童的性别、干预/对照组、胎龄、每个间隔的基线体重和长度变化，以及（2）父母的教育程度、母亲怀孕前的体重、身高和怀孕期间的体重增加，以及父亲在 7 个月时的体重指数。
在调整了儿童和父母的特征后，生命第一年以后的体重增加与 20 岁时的收缩压、腰围和体重指数直接相关。在完全调整的分析中，从出生到 1 岁和 2 岁的体重增加与胰岛素和胰岛素抵抗呈负相关。我们没有发现早期生长与舒张压或血清脂质之间的关系。
生命最初 2 年内的早期体重增加可能预测以后的心血管代谢健康标志物。
