Sweeney Jared, Sheldon Breanna L, Juneja Ankit, Hadanny Amir, Foley Jeffery, Pilitsis Julie G, Sukul Vishad
Department of Neurosurgery, Albany Medical College, Albany, NY, United States.
Department of Neuroscience & Experimental Therapeutics, Albany Medical College, Albany, NY, United States.
Clin Neurol Neurosurg. 2022 May;216:107220. doi: 10.1016/j.clineuro.2022.107220. Epub 2022 Mar 25.
We examine the clinical efficacy of High Frequency 10 kHz (HF10) spinal cord stimulation (SCS) CRPS patients.
This is a retrospective cohort study of SCS-naïve patients with CRPS treated with HF10-SCS after a successful trial. Patients were evaluated at 2 weeks, 6 weeks, 3 months, and 6 months post-operatively. Outcomes included mean numeric pain rating scale (NRS), mean NRS reduction, NRS percentage improvement (PI), patient reported subjective pain PI (Pain PI), and patients reporting > 50% benefit in symptoms. Pre and post-operative NRS were compared by ordinal regression analysis accounting for the patient's response to the SCS trial.
20 patients met inclusion criteria. 75% were female. Mean age 51 years. Baseline mean NRS was 6.1 for the cohort (1.7). Post-operatively, mean NRS decreased to 4.5 at 2 weeks (p = 0.077), 3.8 at 6 weeks (p = 0.034), 3.7 at 3 months (p = 0.307), and 4.4 at 6 months (p = 0.832). Mean NRS reduction and NRS PI is reported within. Pain PI was 25% at 2 weeks, 55% at 6 weeks, 54% at 3 months, and 53% at 6 months. Greater than 50% reduction in symptoms was reported in 25% of patients at 2 weeks, 85% at 6 weeks, 87% at 3 months, and 64% at 6 months.
HF10 SCS may represent an effective treatment option for reducing objective and subjective symptoms in CRPS that warrants further study.
我们研究了高频10kHz（HF10）脊髓刺激（SCS）治疗复杂性区域疼痛综合征（CRPS）患者的临床疗效。
这是一项回顾性队列研究，纳入的是初次接受SCS治疗且在成功试验后接受HF10-SCS治疗的CRPS患者。术后2周、6周、3个月和6个月对患者进行评估。结果包括平均数字疼痛评分量表（NRS）、平均NRS降低值、NRS改善百分比（PI）、患者报告的主观疼痛PI（疼痛PI）以及报告症状改善>50%的患者比例。通过序贯回归分析比较术前和术后NRS，并考虑患者对SCS试验的反应。
20例患者符合纳入标准。75%为女性。平均年龄51岁。该队列的基线平均NRS为6.1（标准差1.7）。术后，2周时平均NRS降至4.5（p = 0.077），6周时降至3.8（p = 0.034），3个月时降至3.7（p = 0.307），6个月时降至4.4（p = 0.832）。文中报告了平均NRS降低值和NRS PI。疼痛PI在2周时为25%，6周时为55%，3个月时为54%，6个月时为53%。25%的患者在2周时报告症状减轻>50%，6周时为85%，3个月时为87%，6个月时为64%。
HF10 SCS可能是一种有效减轻CRPS客观和主观症状的治疗选择，值得进一步研究。
