School of Pharmacy, Hengyang Medical School, Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan 421001, P.R. China.
The Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang, Hunan 421001, P.R. China.
Comb Chem High Throughput Screen. 2022;25(13):2127-2140. doi: 10.2174/1386207325666220401090604.
Multi-drug resistance (MDR) is characterized by the resistance of tumor cells to some antitumor drugs with different structures and mechanisms after the use of a single chemotherapy drug or even the first use of the drug. Notably, MDR has become the largest obstacle to the success of gastric cancer chemotherapies. Non-coding RNAs are defined as a class of RNAs that do not have the ability to code proteins. They are widely involved in important biological functions in life activities. Multiple lines of evidence demonstrated that ncRNAs are closely related to human cancers, including gastric cancer. However, the relationship between ncRNAs and MDR in gastric cancer has been reported, yet the mechanisms are not fully clarified. Therefore, in this review, we systematically summarized the detailed molecular mechanisms of lncRNAs (long noncoding RNAs) and miRNAs (microRNAs) associated with MDR in gastric cancer. Additionally, we speculate that the abnormal expression of ncRNAs is likely to be a novel potential therapeutic target reversing MDR for gastric cancer. Future therapeutics for gastric cancer will most likely be based on noncoding RNAs (ncRNAs) that regulate MDR-related genes.
多药耐药性（MDR）的特征是肿瘤细胞对单一化疗药物甚至首次使用药物后具有不同结构和机制的一些抗肿瘤药物产生耐药性。值得注意的是，MDR 已成为胃癌化疗成功的最大障碍。非编码 RNA 被定义为一类不具有编码蛋白质能力的 RNA。它们广泛参与生命活动中的重要生物学功能。多项证据表明，ncRNA 与人类癌症密切相关，包括胃癌。然而，已有报道称 ncRNA 与胃癌中的 MDR 之间存在关系，但机制尚未完全阐明。因此，在本综述中，我们系统总结了与胃癌 MDR 相关的长链非编码 RNA（lncRNA）和 microRNA（miRNA）的详细分子机制。此外，我们推测 ncRNA 的异常表达可能是一种新型潜在的逆转胃癌 MDR 的治疗靶点。未来针对胃癌的治疗方法很可能基于调节 MDR 相关基因的非编码 RNA（ncRNA）。
