比较埃塞俄比亚亚的斯亚贝巴选定保健中心淋病奈瑟菌和梅毒螺旋体感染的症状与实验室确诊诊断。

Comparison of syndromic versus laboratory-confirmed diagnosis of Neisseria gonorrhoeae and Treponema palladium, infections at the selected health centers in Addis Ababa, Ethiopia.

机构信息

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Department of Microbiology, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.

出版信息

Reprod Health. 2022 Apr 2;19(1):88. doi: 10.1186/s12978-022-01395-w.

DOI:10.1186/s12978-022-01395-w

PMID:35366922

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8976957/

Abstract

BACKGROUND

Sexually transmitted infections (STIs) are major infectious diseases worldwide. Around one million people get STIs every day and among them a high burden of the diseases seen in Sub-Saharan African countries. In most developing countries, including Ethiopia, STIs are diagnosed only using syndromic methods, although there seems to be no consensus between syndromic and laboratory-based research.

OBJECTIVE

To compare the effectiveness of a syndromic versus laboratory-based approach in the diagnosis of sexually transmitted infections, especially Neisseria gonorrhoeae (NG) and Treponema palladium (TP), infections among those attending a public health center in Addis Ababa, Ethiopia.

METHODS

a cross-sectional study was conducted from April 2019 to March 2020, at selected health centers STIs clinics in Addis Ababa, Ethiopia. A total of 325 study participants were involved. From each participant after having socio-demographic data, additional blood, urethral and vaginal discharge was collected. Then serological, Gram stain, culture, and biochemical tests were performed. SPSS version 23 was used to enter and analyze data. All relevant bodies provided ethical approval, and each study participant gave written informed consent.

RESULTS

Among the total participants 167 (51.4%) were males; 177 (54.5%) between ages of 26 and 35; and 178(54.8%) single. Of the total 325 NG, and 125 TP syndromic managed suspected cases, only 163 (50%) and 38 (30.4%) were laboratory- confirmed positive cases respectively. However, there was no statistically significant difference between NG and TP syndromic versus laboratory diagnostic confirmed cases (P-value > 0.005).

CONCLUSION

The present study indicated that even if, there were no statistical differences between syndromic versus Laboratory diagnosis confirmed NG and TP cases, more than half of syndromic cases could not be confirmed by laboratory diagnosed tests. Thus, to strengthen the present findings, further large-scale studies are recommended.

摘要

背景

性传播感染（STIs）是全球范围内的主要传染病。每天约有 100 万人感染 STIs，其中撒哈拉以南非洲国家的疾病负担很高。在包括埃塞俄比亚在内的大多数发展中国家，STIs 仅使用综合征方法进行诊断，尽管综合征和基于实验室的研究之间似乎没有共识。

目的

比较基于综合征和基于实验室的方法在诊断性传播感染方面的效果，特别是在埃塞俄比亚亚的斯亚贝巴的一个公共卫生中心就诊的人群中的淋病奈瑟菌（NG）和梅毒螺旋体（TP）感染。

方法

这是一项横断面研究，于 2019 年 4 月至 2020 年 3 月在埃塞俄比亚亚的斯亚贝巴的选定卫生中心 STIs 诊所进行。共有 325 名研究参与者。从每位参与者收集社会人口统计学数据后，还采集了额外的血液、尿道和阴道分泌物。然后进行血清学、革兰氏染色、培养和生化检测。使用 SPSS 版本 23 输入和分析数据。所有相关机构均提供了伦理批准，每位研究参与者均签署了书面知情同意书。

结果

在总共 325 名参与者中，167 名（51.4%）为男性；177 名（54.5%）年龄在 26 至 35 岁之间；178 名（54.8%）为单身。在总共 325 例 NG 和 125 例 TP 综合征管理疑似病例中，只有 163 例（50%）和 38 例（30.4%）分别为实验室确诊阳性病例。然而，NG 和 TP 综合征与实验室诊断确诊病例之间没有统计学上的显著差异（P 值>0.005）。