Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Diabetes Res Clin Pract. 2022 May;187:109860. doi: 10.1016/j.diabres.2022.109860. Epub 2022 Mar 31.
This study aimed to investigate the relationship between pancreatic fat infiltration (PFI) and glucose metabolism disorder, β-cell function and insulin resistance in patients with obesity.
Pancreatic fat fraction (PFF) was quantified by MRI IDEAL-IQ technique. PFF greater than 6.2 % was defined as PFI, and 34 obese patients were divided into PFI and non-PFI groups. The 5-point plasma glucose and insulin values during oral glucose tolerance test (OGTT) were recorded. OGTT-derived indices of insulin resistance and β-cell function were calculated.
Glucose values levels at 0-120 min during OGTT were significantly higher and β-cell function variables were lower in PFI group than non-PFI group. While indices of insulin resistance were not significantly different between two groups. Correlation analysis showed that PFF was positively correlated with glucose levels at 0, 30 and 60 min, negatively correlated with β-cell function variables and not significantly correlated with indices of insulin resistance. However, these associations of PFF with β-cell function and glucose levels were only present in type 2 diabetes mellitus (T2DM) group but not in non-T2DM group.
There is an association between PFI and impaired β-cell function, and increased pancreatic fat may be a potential risk factor for the development of T2DM.
本研究旨在探讨肥胖患者胰腺脂肪浸润（PFI）与糖代谢紊乱、β细胞功能和胰岛素抵抗之间的关系。
采用 MRI IDEAL-IQ 技术定量检测胰腺脂肪分数（PFF）。PFF 大于 6.2%定义为 PFI，将 34 例肥胖患者分为 PFI 组和非 PFI 组。记录口服葡萄糖耐量试验（OGTT）期间的 5 点血糖和胰岛素值。计算 OGTT 衍生的胰岛素抵抗和β细胞功能指数。
与非 PFI 组相比，PFI 组 OGTT 期间 0-120 分钟的血糖水平显著升高，β细胞功能变量降低。而两组之间胰岛素抵抗指数无显著差异。相关性分析显示，PFF 与 0、30 和 60 分钟时的血糖水平呈正相关，与β细胞功能变量呈负相关，与胰岛素抵抗指数无显著相关性。然而，PFF 与β细胞功能和血糖水平的这些关联仅存在于 2 型糖尿病（T2DM）组，而不存在于非 T2DM 组。
PFI 与β细胞功能受损有关，胰腺脂肪增加可能是 T2DM 发生的潜在危险因素。
