Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Laboratory of Endocrine Physiology, Department of Physiological Sciences, State University of Rio de Janeiro, Rio de Janeiro, RJ, 20551-030, Brazil.
Sci Rep. 2024 May 31;14(1):12530. doi: 10.1038/s41598-024-63488-9.
Growing obesity is linked to shifts in dietary patterns, particularly the increased intake of ultra-processed high-fat foods. This study aimed to evaluate the effects of interesterified palm oil consumption on glucose homeostasis, adipose tissue remodeling, and hepatic lipogenesis in C57BL/6 mice fed a high-fat diet. Sixty C57BL/6 mice were divided into four groups (n = 15): the control group (C) fed a standard diet (4% soybean oil), the high-fat group (HF) (23.8% lard), the high palm oil fat group (HFP) (23.8% palm oil), and the high interesterified palm fat group (HFI) (23.8% interesterified palm oil) for 8 weeks (all groups received 50% energy from lipids). The HFI group exhibited higher body mass than the HF group (+ 11%, P < 0.05), which was attributed to an increased percentage of fat mass. Plasma concentrations of IL-6, insulin, and HOMA-IR were also elevated in the HFI group. Both the HFP and HFI groups showed hypertrophied adipocytes and pancreatic islets, increased alpha and beta cell masses, hepatic steatosis, low expression of genes related to beta-oxidation, and upregulated lipogenesis. In conclusion, the consumption of interesterified palm oil alters inflammatory and glucose profiles.
肥胖症的增长与饮食模式的转变有关，特别是高脂肪的超加工食品摄入量的增加。本研究旨在评估反式棕榈油对高脂肪饮食喂养的 C57BL/6 小鼠葡萄糖稳态、脂肪组织重塑和肝内脂肪生成的影响。将 60 只 C57BL/6 小鼠分为四组（n = 15）：对照组（C）喂食标准饮食（4%大豆油），高脂肪组（HF）（23.8%猪油），高棕榈油脂肪组（HFP）（23.8%棕榈油）和高反式棕榈油脂肪组（HFI）（23.8%反式棕榈油），共 8 周（所有组的脂质提供 50%的能量）。与 HF 组相比，HFI 组的体重增加更多（+11%，P<0.05），这归因于脂肪量的增加。HFI 组的血浆 IL-6、胰岛素和 HOMA-IR 浓度也升高。HFP 和 HFI 组均表现出脂肪细胞和胰岛肥大、α和β细胞质量增加、肝脂肪变性、与β氧化相关的基因表达降低以及脂肪生成上调。总之，反式棕榈油的摄入改变了炎症和葡萄糖谱。
