星形诺卡菌感染的库普弗细胞和腹膜巨噬细胞中溶酶体蛋白酶 - 酯酶及溶菌酶的调节
Modulation of lysosomal protease-esterase and lysozyme in Kupffer cells and peritoneal macrophages infected with Nocardia asteroides.
作者信息
Black C M, Paliescheskey M, Beaman B L, Donovan R M, Goldstein E
出版信息
Infect Immun. 1986 Dec;54(3):917-9. doi: 10.1128/iai.54.3.917-919.1986.
Abstract
Virulent Nocardia asteroides reduces lysosomal acid phosphatase activity in murine macrophages. A computer-assisted imaging photometry system was used to quantitate lysozyme and nonspecific esterase-neutral protease levels within individual macrophages following ingestion of nocardiae. In contrast to acid phosphatase, lysozyme and esterase-neutral protease activity was either unchanged or increased following infection by increasing numbers of nocardial cells.
摘要
强毒星形诺卡菌可降低小鼠巨噬细胞中的溶酶体酸性磷酸酶活性。使用计算机辅助成像光度测定系统对摄入诺卡菌后单个巨噬细胞内的溶菌酶和非特异性酯酶-中性蛋白酶水平进行定量。与酸性磷酸酶不同，随着诺卡菌细胞数量增加，感染后溶菌酶和酯酶-中性蛋白酶活性要么未改变，要么增加。
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