Zhu Ying, Yan Ai, Shu Bin, Chen Xuehan, Chen Yupei, Duan Guangyou, Huang He
Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Front Neurosci. 2022 Mar 16;16:810166. doi: 10.3389/fnins.2022.810166. eCollection 2022.
The diurnal rhythm profile of human basal pain sensitivity and its association with sympathetic nerve activity are not fully understood. This study aimed to examine rhythmic changes in experimental pain sensitivity and skin sympathetic nerve activity in healthy volunteers.
Thirty healthy volunteers were included in the study. Experimental pain sensitivity, including pressure pain threshold and tolerance, cold pain threshold (CPT) and tolerance, skin sympathetic nerve activity, and cardiovascular parameters (including heart rate, cardiac output, and peripheral vascular resistance) at six time points throughout the day (08:00, 12:00, 16:00, 20:00, 00:00, and 04:00) were sequentially measured. Circadian rhythm analysis was performed on the mean values of the different measurements and individual subjects.
Significant differences were found in experimental pain sensitivity, skin sympathetic nerve activity, and non-invasive cardiovascular parameters at different time points ( < 0.05). The minimum measured values of all four types of experimental pain sensitivity were consistently observed at 04:00. Rhythmical analysis showed that the mean values of pressure pain threshold (meta2d = 0.016) and skin sympathetic nerve activity (meta2d = 0.039) were significant. Significant diurnal rhythms in pain sensitivity and skin sympathetic nerve activity existed in some individuals but not in others. No significant correlation between experimental pain sensitivity and skin sympathetic nerve activity was found at any time point ( > 0.05).
Significant diurnal fluctuations were observed in different pain sensitivities and skin sympathetic nerve activity. No significant correlation between experimental pain sensitivity and sympathetic excitability at different times was found; the reasons for these phenomena remain to be further studied.
[www.ClinicalTrials.gov], identifier [ChiCTR2000039709].
人类基础疼痛敏感性的昼夜节律特征及其与交感神经活动的关联尚未完全明确。本研究旨在检测健康志愿者实验性疼痛敏感性和皮肤交感神经活动的节律性变化。
30名健康志愿者纳入本研究。在一天中的六个时间点（08:00、12:00、16:00、20:00、00:00和04:00）依次测量实验性疼痛敏感性，包括压力痛阈和耐受、冷痛阈（CPT）和耐受、皮肤交感神经活动以及心血管参数（包括心率、心输出量和外周血管阻力）。对不同测量值和个体受试者的平均值进行昼夜节律分析。
在不同时间点，实验性疼痛敏感性、皮肤交感神经活动和非侵入性心血管参数存在显著差异（<0.05）。所有四种类型的实验性疼痛敏感性的最低测量值均在04:00一致观察到。节律分析表明，压力痛阈（meta2d = 0.016）和皮肤交感神经活动（meta2d = 0.039）的平均值具有显著性。部分个体存在疼痛敏感性和皮肤交感神经活动的显著昼夜节律，而其他个体则不存在。在任何时间点，实验性疼痛敏感性与皮肤交感神经活动之间均未发现显著相关性（>0.05）。
不同疼痛敏感性和皮肤交感神经活动存在显著的昼夜波动。不同时间点实验性疼痛敏感性与交感神经兴奋性之间未发现显著相关性；这些现象的原因仍有待进一步研究。
