昼夜节律、疼痛和阿片类药物之间的破坏关系。
The disruptive relationship among circadian rhythms, pain, and opioids.
作者信息
Bumgarner Jacob R, McCray Evan W, Nelson Randy J
机构信息
Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.
出版信息
Front Neurosci. 2023 Feb 15;17:1109480. doi: 10.3389/fnins.2023.1109480. eCollection 2023.
Abstract
Pain behavior and the systems that mediate opioid analgesia and opioid reward processing display circadian rhythms. Moreover, the pain system and opioid processing systems, including the mesolimbic reward circuitry, reciprocally interact with the circadian system. Recent work has demonstrated the disruptive relationship among these three systems. Disruption of circadian rhythms can exacerbate pain behavior and modulate opioid processing, and pain and opioids can influence circadian rhythms. This review highlights evidence demonstrating the relationship among the circadian, pain, and opioid systems. Evidence of how disruption of one of these systems can lead to reciprocal disruptions of the other is then reviewed. Finally, we discuss the interconnected nature of these systems to emphasize the importance of their interactions in therapeutic contexts.
摘要
疼痛行为以及介导阿片类镇痛和阿片类奖赏处理的系统呈现昼夜节律。此外，疼痛系统和阿片类处理系统，包括中脑边缘奖赏回路，与昼夜节律系统相互作用。最近的研究表明了这三个系统之间的破坏关系。昼夜节律的破坏会加剧疼痛行为并调节阿片类处理，而疼痛和阿片类药物会影响昼夜节律。本综述重点介绍了证明昼夜节律、疼痛和阿片类系统之间关系的证据。然后回顾了其中一个系统的破坏如何导致另一个系统的相互破坏的证据。最后，我们讨论了这些系统的相互联系性质，以强调它们在治疗环境中相互作用的重要性。
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