Stoliker Devon, Egan Gary F, Razi Adeel
Turner Institute for Brain and Mental Health, Monash University, Clayton, VIC, Australia.
Monash Biomedical Imaging, Monash University, Clayton, VIC, Australia.
Front Neurosci. 2022 Mar 17;16:827400. doi: 10.3389/fnins.2022.827400. eCollection 2022.
Evidence suggests classic psychedelics reduce the precision of belief updating and enable access to a range of alternate hypotheses that underwrite how we make sense of the world. This process, in the higher cortices, has been postulated to explain the therapeutic efficacy of psychedelics for the treatment of internalizing disorders. We argue reduced precision also underpins change to consciousness, known as "," and that alterations to consciousness and attention under psychedelics have a common mechanism of reduced precision of Bayesian belief updating. Evidence, connecting the role of serotonergic receptors to large-scale connectivity changes in the cortex, suggests the precision of Bayesian belief updating may be a mechanism to modify and investigate consciousness and attention.
有证据表明，经典迷幻剂会降低信念更新的精确度，并使人能够接触到一系列替代假设，这些假设支撑着我们理解世界的方式。在大脑高级皮质中，这一过程被认为可以解释迷幻剂治疗内化性障碍的疗效。我们认为，精确度降低也是“[此处原文缺失特定术语]”这种意识改变的基础，并且迷幻剂作用下的意识和注意力改变具有贝叶斯信念更新精确度降低这一共同机制。将血清素能受体的作用与皮质中大规模连接变化联系起来的证据表明，贝叶斯信念更新的精确度可能是一种调节和研究意识与注意力的机制。
