Chugh Yashika, Katoch Swati, Sharma Deepshikha, Bahuguna Pankaj, Duseja Ajay, Kaur Manmeet, Dhiman Radha Krishan, Prinja Shankar
Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Community Med. 2022 Jan-Mar;47(1):76-81. doi: 10.4103/ijcm.ijcm_1033_21. Epub 2022 Mar 16.
The present study aims to determine the health-related quality of life (HRQoL) among liver disorder patients being treated in tertiary care hospital in north India and exploration of factors affecting HRQoL.
The HRQoL was assessed among 230 patients visiting either the outpatient department (OPD) or those admitted in high dependency unit (HDU) or liver intensive care unit (ICU) using direct measuring tools such as Euro QoL five-dimension questionnaire (EQ-5D) and EQ visual analog scale. Multivariate regression was used to explore the factors influencing HRQoL.
Mean EQ-5D scores among chronic hepatitis and compensated cirrhosis patients were 0.639 ± 0.062 and 0.562 ± 0.048, respectively. Among those who were admitted in the ICU or HDU, mean EQ-5D score was 0.295 ± 0.031. At discharge, this score improved significantly to 0.445 ± 0.055 ( < 0.001). The multivariate results implied that HRQoL was significantly better among patients with lower literacy level ( = 0.018) and those treated in OPD settings ( < 0.001).
HRQoL is impaired among patients suffering from liver disorders specifically those admitted in ICU. Further, there is a need to generate more evidence to explore the impact of determinants and treatment-associated costs on the HRQoL.
本研究旨在确定印度北部三级医院接受治疗的肝病患者的健康相关生活质量（HRQoL），并探究影响HRQoL的因素。
使用直接测量工具，如欧洲五维健康量表（EQ-5D）和EQ视觉模拟量表，对230名门诊患者、高依赖病房（HDU）或肝脏重症监护病房（ICU）的住院患者的HRQoL进行评估。采用多元回归分析来探究影响HRQoL的因素。
慢性肝炎和代偿期肝硬化患者的平均EQ-5D得分分别为0.639±0.062和0.562±0.048。在ICU或HDU住院的患者中，平均EQ-5D得分为0.295±0.031。出院时，该得分显著提高至0.445±0.055（<0.001）。多元分析结果表明，识字水平较低的患者（P=0.018）和在门诊接受治疗的患者（P<0.001）的HRQoL明显更好。
肝病患者，尤其是入住ICU的患者，其HRQoL受损。此外，需要更多证据来探究决定因素和治疗相关成本对HRQoL的影响。
