Hubert Jean-Noël, Demars Julie
GenPhySE, Université de Toulouse, INRAE, ENVT, F-31326, Castanet Tolosan, France.
Front Genet. 2022 Mar 15;13:838534. doi: 10.3389/fgene.2022.838534. eCollection 2022.
Genomic imprinting represents a noteworthy inheritance mechanism leading to allele-specific regulations dependent of the parental origin. Imprinted loci are especially involved in essential mammalian functions related to growth, development and behavior. In this mini-review, we first offer a summary of current representations associated with genomic imprinting through key results of the three last decades. We then outline new perspectives allowed by the spread of new omics technologies tackling various interacting levels of imprinting regulations, including genomics, transcriptomics and epigenomics. We finally discuss the expected contribution of new omics data to unresolved big questions in the field.
基因组印记是一种值得关注的遗传机制，它导致了依赖亲本来源的等位基因特异性调控。印记基因座尤其参与了与生长、发育和行为相关的基本哺乳动物功能。在这篇小型综述中，我们首先通过过去三十年的关键研究成果，总结了与基因组印记相关的当前认知。然后，我们概述了新的组学技术的广泛应用所带来的新视角，这些技术涉及印记调控的各个相互作用层面，包括基因组学、转录组学和表观基因组学。最后，我们讨论了新的组学数据对该领域尚未解决的重大问题的预期贡献。
