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酿酒酵母中MFα2编码的α因子类似物的凝集和交配活性。

Agglutination and mating activity of the MF alpha 2-encoded alpha-factor analog in Saccharomyces cerevisiae.

作者信息

Kurjan J, Lipke P N

出版信息

J Bacteriol. 1986 Dec;168(3):1472-5. doi: 10.1128/jb.168.3.1472-1475.1986.

DOI:10.1128/jb.168.3.1472-1475.1986
PMID:3536884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC213665/
Abstract

The MF alpha 2-encoded Asn-5,Arg-7 alpha-factor-like peptide has been shown shown to have similar activity to Gln-5,Lys-7 alpha-factor in morphogenesis and growth arrest studies (S. Raths, P. Shenbagamurthi, F. Naider, and J. M. Becker, J. Bacteriol. 168:1468-1471, 1986). We tested the Asn-5,Arg-7 peptide in agglutination and mating assays and found that its activity was similar to or slightly less than that of the Gln-5,Lys-7 alpha-factor. The Asn-5,Arg-7 alpha-factor-like peptide is thus the most active analog of the Gln-5,Lys-7 alpha-factor known.

摘要

在形态发生和生长停滞研究中，已证明由MF alpha 2编码的Asn-5、Arg-7α因子样肽与Gln-5、Lys-7α因子具有相似活性（S. Raths、P. Shenbagamurthi、F. Naider和J. M. Becker，《细菌学杂志》168:1468 - 1471，1986年）。我们在凝集和交配试验中测试了Asn-5、Arg-7肽，发现其活性与Gln-5、Lys-7α因子相似或略低。因此，Asn-5、Arg-7α因子样肽是已知的Gln-5、Lys-7α因子中活性最高的类似物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2b6/213665/7a2628aa30b3/jbacter00205-0434-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2b6/213665/7a2628aa30b3/jbacter00205-0434-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2b6/213665/7a2628aa30b3/jbacter00205-0434-a.jpg

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引用本文的文献

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Role of alpha-factor and the MF alpha 1 alpha-factor precursor in mating in yeast.α-因子和MFα1α-因子前体在酵母交配中的作用。
Genetics. 1991 Feb;127(2):299-307. doi: 10.1093/genetics/127.2.299.

本文引用的文献

1
Inactivation and chemical alteration of mating factor alpha by cells and spheroplasts of yeast.酵母细胞和原生质球对交配因子α的失活及化学改变
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Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.对因一种因子和α因子信息素而对G1期阻滞超敏感的酿酒酵母突变体的分离与遗传分析。
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Sexual agglutination in Saccharomyces cerevisiae.
酿酒酵母中的性凝集作用。
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Structure of a yeast pheromone gene (MF alpha): a putative alpha-factor precursor contains four tandem copies of mature alpha-factor.酵母信息素基因（MFα）的结构：一种假定的α-因子前体包含四个成熟α-因子的串联拷贝。
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Different structure-function relationships for alpha-factor-induced morphogenesis and agglutination in Saccharomyces cerevisiae.酿酒酵母中α-因子诱导的形态发生和凝集的不同结构-功能关系。
J Bacteriol. 1984 Jun;158(3):1152-6. doi: 10.1128/jb.158.3.1152-1156.1984.
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Comparison of dose-response curves for alpha factor-induced cell division arrest, agglutination, and projection formation of yeast cells. Implication for the mechanism of alpha factor action.α因子诱导酵母细胞分裂停滞、凝集和突起形成的剂量反应曲线比较。对α因子作用机制的启示。
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Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase.酵母α因子是由一种更大的前体多肽加工而来：一种膜结合二肽基氨肽酶的重要作用。
Cell. 1983 Mar;32(3):839-52. doi: 10.1016/0092-8674(83)90070-3.
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One-step gene disruption in yeast.酵母中的一步基因破坏
Methods Enzymol. 1983;101:202-11. doi: 10.1016/0076-6879(83)01015-0.
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Saccharomyces cerevisiae contains two discrete genes coding for the alpha-factor pheromone.酿酒酵母包含两个编码α因子信息素的不同基因。
Nucleic Acids Res. 1983 Jun 25;11(12):4049-63. doi: 10.1093/nar/11.12.4049.
10
Mutations affecting sexual conjugation and related processes in Saccharomyces cerevisiae. I. Isolation and phenotypic characterization of nonmating mutants.影响酿酒酵母有性接合及相关过程的突变。I. 非交配突变体的分离与表型特征分析
Genetics. 1974 Feb;76(2):255-71. doi: 10.1093/genetics/76.2.255.