Department of Reproductive, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Medical Section, Jiangxi Cancer Hospital, Nanchang 330029, Jiangxi Province, China.
J Healthc Eng. 2022 Mar 24;2022:5319172. doi: 10.1155/2022/5319172. eCollection 2022.
To explore the clinical efficacy of assisted reproductive technology (ART) combined with progesterone capsules in the treatment of infertility caused by the diminished ovarian reserve (DOR) and its influence on serum FSH, E2, and LH levels of patients.
In the manner of retrospective study, the data of 120 patients with infertility caused by DOR admitted to our hospital (February 2019-February 2020) were retrospectively analyzed, and the patients were equally divided into the experimental group and the control group according to the order of admission. All patients underwent in vitro fertilization and embryo transfer (IVF-ET), and the experimental group was received progesterone capsules at the same time. Ovarian-related indexes, follicular development, serum hormone levels, and pregnancy outcomes were compared between both groups.
After treatment, compared with the control group, ovarian-related indexes and follicular development in the experimental group were conspicuously better ( < 0.001). In the experimental group, the FSH level was (5.99 ± 1.20) U/L, the E level was (540.12 ± 3.54) ng/L, and the LH level was (3.10 ± 0.35) U/L after treatment, which was significantly better than those of the control group ( < 0.001). After treatment, compared with the control group, the clinical pregnancy rate in the experimental group was conspicuously higher ( < 0.05), and the abortion rate in the experimental group was conspicuously lower ( < 0.05). No obvious difference was observed in multiple births rate between the two groups ( > 0.05).
ART combined with progesterone capsules can improve serum hormone levels, ovarian function, follicular development, and clinical pregnancy rate for patients with infertility caused by DOR, which should be applied in practice.
探讨辅助生殖技术（ART）联合黄体酮胶囊治疗卵巢储备功能减退（DOR）所致不孕的临床疗效及其对患者血清 FSH、E2、LH 水平的影响。
采用回顾性研究方法，分析 2019 年 2 月至 2020 年 2 月我院收治的 120 例 DOR 所致不孕患者的临床资料，根据入院顺序将患者等分为实验组和对照组。两组患者均行体外受精-胚胎移植（IVF-ET）治疗，实验组同时口服黄体酮胶囊。比较两组患者的卵巢相关指标、卵泡发育情况、血清激素水平及妊娠结局。
治疗后，实验组患者的卵巢相关指标和卵泡发育情况明显优于对照组（ < 0.001）。实验组患者 FSH 水平为（5.99±1.20）U/L，E2 水平为（540.12±3.54）ng/L，LH 水平为（3.10±0.35）U/L，均明显优于对照组（ < 0.001）。治疗后，实验组患者的临床妊娠率明显高于对照组（ < 0.05），流产率明显低于对照组（ < 0.05），两组患者的多胎妊娠率比较差异无统计学意义（ > 0.05）。
ART 联合黄体酮胶囊可改善 DOR 所致不孕患者的血清激素水平、卵巢功能、卵泡发育情况及临床妊娠率，值得临床推广应用。
