DNA加合物与细胞周期
DNA adducts and cell cycle.
作者信息
Rabes H M
出版信息
J Cancer Res Clin Oncol. 1986;112(3):189-95. doi: 10.1007/BF00395911.
Abstract
Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-related genes replicating at critical phases of DNA synthesis, or cell cycle-related differences in the repair of DNA adducts. Some recent data on these subjects are summarized, mainly in context of cell cycle-dependent transformation sensitivity of regenerating rat liver.
摘要
转化敏感性的细胞周期依赖性差异可能归因于细胞周期中最终亲电致癌物形成的改变、细胞周期特定阶段优先形成的初级加合物，例如在复制叉处与单链DNA结合、DNA合成关键阶段复制的转化相关基因的碱基错配和突变，或DNA加合物修复中与细胞周期相关的差异。本文总结了关于这些主题的一些最新数据，主要围绕再生大鼠肝脏的细胞周期依赖性转化敏感性。
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