Liu Yang, Wang Qiang, Zheng Dong-Kun, Zhang De, Xie Zhen, Hu Jia-Wei, Xie Xin-Hua, Li Jing, Jiang Shu-Ping
Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, 341000, China.
National Engineering Research Center for Modernization of Traditional Chinese Medicine - Hakka Medical Resources Branch, College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi, China.
Nat Prod Res. 2022 Dec;36(23):6006-6011. doi: 10.1080/14786419.2022.2059662. Epub 2022 Apr 4.
Two new abietane diterpenoids, phlecarinatone A () and phlecarinatone B (), along with two known analogues ( and ), were isolated from . The structures of were unambiguously elucidated by comprehensive spectroscopic analyses. Abietane diterpenoids were isolated from the plant for the first time. All isolates were tested for their neuroprotective activities against HO-induced SH-SY5Y cells injury, and compound 2 showed moderate effect at the concentrations ranging from 5 ∼ 20 μM in vitro assay.
从[植物名称未给出]中分离出了两种新的枞酸型二萜类化合物，即去氢枞酸内酯A（）和去氢枞酸内酯B（），以及两种已知类似物（和）。通过全面的光谱分析明确阐明了它们的结构。这是首次从该植物中分离出枞酸型二萜类化合物。对所有分离物进行了针对HO诱导的SH-SY5Y细胞损伤的神经保护活性测试，在体外实验中，化合物2在5至20μM的浓度范围内显示出中等效果。
