Department of Dermatology, University of Wisconsin, 1 South Park Street, Madison, WI 53703, USA.
Department of Dermatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Crit Care Clin. 2022 Apr;38(2):243-269. doi: 10.1016/j.ccc.2021.11.003.
There have been major advances in the understanding of severe cutaneous adverse reactions (SCARs). Early recognition and withdrawal of culprit medications can decrease morbidity and mortality significantly. SCARs encompass a variety of entities that present with extensive mucocutaneous involvement and systemic symptoms, often requiring management in an intensive care setting. Physicians need to recognize SCARs early in their course, including drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis, and their mimicking conditions. This review focuses on common and rare SCARs with an emphasis on defining features, clinical and diagnostic evaluation, treatment, and long-term sequelae.
在严重皮肤不良反应（SCARs）的理解方面已经取得了重大进展。早期识别和停用致病药物可以显著降低发病率和死亡率。SCARs 包括多种表现为广泛黏膜皮肤受累和全身症状的实体，通常需要在重症监护环境中进行管理。医生需要在病程早期识别出 SCARs，包括药物反应伴嗜酸性粒细胞增多和全身症状、史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症及其类似疾病。本综述重点介绍常见和罕见的 SCARs，强调其特征、临床和诊断评估、治疗和长期后遗症。
