Gill A M, Leach H J, Hughes J, Barker C, Nunn A J, Choonara I
Department of Pharmacy, Alder Hey Children's Hospital, Liverpool, UK.
Acta Paediatr. 1995 Apr;84(4):438-41. doi: 10.1111/j.1651-2227.1995.tb13667.x.
Adverse drug reactions (ADRs) were prospectively studied in critically ill infants and children. Seventy-six ADRs were reported in 63 patients out of a study group of 899 patients. The majority of the ADRs were mild (49), although 19 were of moderate severity and 8 were severe. Thirty-five ADRs required treatment or alteration in treatment. Midazolam, morphine, salbutamol, vecuronium, hydrocortisone and theophylline were the drugs most likely to cause an ADR. One-third of the ADRs were due to drugs used outside their product licence. The majority of the ADRs were reported by nurses (36) and pharmacists (30). We believe that it is possible to prospectively study drug toxicity in critically ill infants and children.
对危重症婴幼儿和儿童的药物不良反应（ADR）进行了前瞻性研究。在899名研究对象中，63名患者报告了76例药物不良反应。大多数不良反应为轻度（49例），尽管19例为中度，8例为重度。35例不良反应需要治疗或调整治疗方案。咪达唑仑、吗啡、沙丁胺醇、维库溴铵、氢化可的松和茶碱是最有可能引起不良反应的药物。三分之一的不良反应是由于超适应证用药引起的。大多数不良反应是由护士（36例）和药剂师（30例）报告的。我们认为，对危重症婴幼儿和儿童的药物毒性进行前瞻性研究是可行的。
