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甲状腺疾病的干细胞治疗：进展与挑战

Stem Cell Therapy for Thyroid Diseases: Progress and Challenges.

作者信息

Ye Sunyi, Zhu Zhu Lixian

机构信息

Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

出版信息

Curr Ther Res Clin Exp. 2022 Mar 5;96:100665. doi: 10.1016/j.curtheres.2022.100665. eCollection 2022.

DOI:10.1016/j.curtheres.2022.100665
PMID:35371349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8968462/
Abstract

BACKGROUND

Thyroid hormones are indispensable for organ development and maintaining homeostasis. Thyroid diseases, including thyroiditis and thyroid cancer, affect the normal secretion of hormones and result in thyroid dysfunction.

OBJECTIVE

This review focuses on therapeutic applications of stem cells for thyroid diseases.

METHODS

A literature search of Medline and PubMed was conducted (January 2000-July 2021) to identify recent reports on stem cell therapy for thyroid diseases.

RESULTS

Stem cells are partially developed cell types. They have the capacity to form specialized cells. Besides embryonic stem cells and mesenchymal stem cells, organ resident stem cells and cancer stem cells are recently reported to have important roles in forming organ specific cells and cancers. Stem cells, especially mesenchymal stem cells, have anti-inflammatory and anticancer functions as well.

CONCLUSIONS

This review outlines the therapeutic potency of embryonic stem cells, mesenchymal stem cells, thyroid resident stem cells, and thyroid cancer stem cells in thyroid cells' regeneration, thyroid function modulation, thyroiditis suppression, and antithyroid cancers. Stem cells represent a promising form of treatment for thyroid disorders.

摘要

背景

甲状腺激素对于器官发育和维持体内平衡不可或缺。甲状腺疾病，包括甲状腺炎和甲状腺癌，会影响激素的正常分泌并导致甲状腺功能障碍。

目的

本综述聚焦于干细胞在甲状腺疾病治疗中的应用。

方法

检索了Medline和PubMed数据库（2000年1月至2021年7月），以查找有关干细胞治疗甲状腺疾病的最新报道。

结果

干细胞是部分发育的细胞类型。它们具有形成特化细胞的能力。除了胚胎干细胞和间充质干细胞外，最近报道器官驻留干细胞和癌症干细胞在形成器官特异性细胞和癌症方面也具有重要作用。干细胞，尤其是间充质干细胞，还具有抗炎和抗癌功能。

结论

本综述概述了胚胎干细胞、间充质干细胞、甲状腺驻留干细胞和甲状腺癌干细胞在甲状腺细胞再生、甲状腺功能调节、甲状腺炎抑制和抗甲状腺癌方面的治疗潜力。干细胞是甲状腺疾病一种很有前景的治疗形式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5749/8968462/40194c8bd793/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5749/8968462/b47f9f7d4d41/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5749/8968462/8b11d51578d9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5749/8968462/40194c8bd793/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5749/8968462/b47f9f7d4d41/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5749/8968462/8b11d51578d9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5749/8968462/40194c8bd793/gr3.jpg

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Cells. 2021 Oct 26;10(11):2897. doi: 10.3390/cells10112897.
2
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Stem Cell Res Ther. 2021 May 29;12(1):304. doi: 10.1186/s13287-021-02337-2.
3
A Stem Cell Surge During Thyroid Regeneration.
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