Turakulov Ia Kh, Artemova E P, Rasulev N I, Nusratova D
Biull Eksp Biol Med. 1981 Sep;92(9):295-6.
Secretory thyroid function was studied in animals with experimental autoimmune thyroiditis and in rats with passive immunization by antithyroid antibodies. The lowering of colloid endocytosis and thyroglobulin proteolysis accompanied by complete suppression of total thyroxin secretion stimulation was shown to occur in autoimmune thyroiditis. Injection to the rats of antibodies in the form of IgG gamma 2 fraction led to the reduced colloid output from the follicles, diminished secretion of triiodothyronine and to a pronounced suppression of thyroxin secretion stimulation. It is concluded that the lowering of colloid endocytosis and proteolytic enzymes is caused by insufficient production of TSH. Antithyroid antibodies should be treated as responsible for suppressed thyroxin secretion into the blood.
对患有实验性自身免疫性甲状腺炎的动物以及通过抗甲状腺抗体进行被动免疫的大鼠的分泌性甲状腺功能进行了研究。结果表明，在自身免疫性甲状腺炎中，胶体胞吞作用和甲状腺球蛋白蛋白水解作用降低，同时总甲状腺素分泌刺激被完全抑制。以IgGγ2 组分形式向大鼠注射抗体导致滤泡胶体排出减少、三碘甲状腺原氨酸分泌减少以及甲状腺素分泌刺激明显受到抑制。得出的结论是，胶体胞吞作用和蛋白水解酶的降低是由促甲状腺激素分泌不足引起的。抗甲状腺抗体应被视为导致甲状腺素分泌入血受到抑制的原因。
