Vatansever Sezgin, Özer Merve Kılınç, Erdoğan Elvan Işık
Department of Gastroenterology, Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
Department of Internal Medicine, Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
Prz Gastroenterol. 2022;17(1):35-40. doi: 10.5114/pg.2022.114595. Epub 2022 Mar 18.
α-fetoprotein (AFP)-producing gastric carcinoma is a rare type of gastric cancer. Compared with other types, it is more aggressive and prone to liver metastases.
To investigate the prognostic characteristics of AFP in patients with gastric adenocarcinoma.
Our study included 391 patients diagnosed with gastric adenocarcinoma, who were admitted between 2006 and 2019. For all patients, demographic characteristics, location of the lesion, levels of AFP, CEA, and CA19-9, pathology diagnosis, results of operation, and survival status were recorded.
In our study, 68.3% of the patients were male, and the mean age was 62.76 years. In 66 (16.9%) patients, AFP level (cut-off = 8.2 ng/dl) was higher than normal. A total of 26 cases were with AFP > 100 ng/ml. 92.3% of cases with positive AFP gastric cancer were stage 4, and liver metastasis was detected in 80.8%. No significant difference was found between groups with AFP levels of < 100 ng/ml and ≥ 100 ng/ml in terms of gender, location of the lesion, or stage of the tumour. An AFP value higher than 100 ng/ml was significantly associated with liver metastasis, pathological diagnoses, and metastasis status. There was a significant difference in mortality between AFP > 100 ng/ml and age.
Predictors with high predictive value are needed for early diagnosis and screening of gastric cancer. We thought that comprehensive studies on this subject would contribute to the literature and reduce the mortality and economic losses by determining the prognosis of gastric cancer.
产生甲胎蛋白（AFP）的胃癌是一种罕见的胃癌类型。与其他类型相比，它侵袭性更强，更容易发生肝转移。
研究AFP在胃腺癌患者中的预后特征。
我们的研究纳入了2006年至2019年间收治的391例诊断为胃腺癌的患者。记录了所有患者的人口统计学特征、病变部位、AFP、癌胚抗原（CEA）和糖类抗原19-9（CA19-9）水平、病理诊断、手术结果和生存状况。
在我们的研究中，68.3%的患者为男性，平均年龄为62.76岁。66例（16.9%）患者的AFP水平（临界值 = 8.2 ng/dl）高于正常。共有26例患者的AFP>100 ng/ml。AFP阳性胃癌患者中92.3%为IV期，80.8%检测到肝转移。AFP水平<100 ng/ml和≥100 ng/ml的两组在性别、病变部位或肿瘤分期方面无显著差异。AFP值高于100 ng/ml与肝转移、病理诊断和转移状态显著相关。AFP>100 ng/ml与年龄之间的死亡率存在显著差异。
胃癌的早期诊断和筛查需要具有高预测价值的预测指标。我们认为对此主题的综合研究将有助于文献报道，并通过确定胃癌的预后降低死亡率和经济损失。
