Jaitpal Varun, Gawande Sushil
Psychiatry, NKP (Narendra Kumar Prasadrao) Salve Institute of Medical Sciences and Lata Mangeshkar Hospital, Nagpur, IND.
Cureus. 2022 Feb 17;14(2):e22327. doi: 10.7759/cureus.22327. eCollection 2022 Feb.
This case report describes a 22-year-old male patient diagnosed with schizoaffective disorder. A multidrug regimen including olanzapine and lorazepam was initiated for the patient. Sodium valproate was added to the regimen in due course and it was associated with bicytopenia in the form of thrombocytopenia and leukopenia. Valproate was identified as the offending drug and further doses were withheld. Lithium was used as a substitute to valproate and the patient spontaneously recovered without any further complications. This case report highlights the necessity of periodic investigations and frequent logging of blood indices to counter the threat of fatal adverse drug reactions.
本病例报告描述了一名22岁被诊断为精神分裂症的男性患者。为该患者启动了包括奥氮平和劳拉西泮在内的多药治疗方案。丙戊酸钠在适当的时候被加入该方案，并且它与血小板减少症和白细胞减少症形式的双血细胞减少有关。丙戊酸盐被确定为致病药物，后续剂量被停用。锂盐被用作丙戊酸盐的替代药物，患者自行康复且无任何进一步并发症。本病例报告强调了定期检查和频繁记录血液指标以应对致命药物不良反应威胁的必要性。
