Taniguchi A, Kono T, Okuda H, Oseko F, Nagata I, Kataoka K, Imura H
J Lipid Res. 1986 Sep;27(9):925-9.
Basal and insulin-stimulated neutral glyceride syntheses from glucose were studied in fat cells of different size (fat cell volume, 0.07-0.20, 0.20-0.60, 0.60-1.00, 1.00-1.50 micron3 X 10(6)) obtained from subcutaneous adipose tissues in 20 subjects aged 3 months to 67 years. In 0.07-0.20 or 0.20-0.60 micron3 X 10(6) fat cells, the basal rate of glucose conversion to neutral glyceride was significantly lower in mature (36 to 67 years old) than in growing (0 to 12 years old) subjects. In 0.60-1.00 or 1.00-1.50 micron3 X 10(6) fat cells, however, basal rate was not significantly different between the two groups. The stimulating effect of insulin on conversion of glucose to neutral glyceride was not significantly different from the basal rate in fat cells of each size taken from the mature subjects, whereas in fat cells from growing subjects, it was significantly different from the basal rate in each fat cell size category. These results indicate that when fat cell size is taken into account, not only is the rate of basal glucose conversion to neutral glyceride higher in growing subjects but also its responsiveness to exogenous insulin, and that insulin insensitivity of large fat cells, reported previously, may be influenced by age.
对20名年龄从3个月到67岁的受试者皮下脂肪组织中获取的不同大小（脂肪细胞体积，0.07 - 0.20、0.20 - 0.60、0.60 - 1.00、1.00 - 1.50立方微米×10⁶）的脂肪细胞，研究了基础状态及胰岛素刺激下葡萄糖向中性甘油酯的合成情况。在体积为0.07 - 0.20或0.20 - 0.60立方微米×10⁶的脂肪细胞中，成熟（36至67岁）受试者葡萄糖转化为中性甘油酯的基础速率显著低于生长中（0至12岁）的受试者。然而，在体积为0.60 - 1.00或1.00 - 1.50立方微米×10⁶的脂肪细胞中，两组之间的基础速率没有显著差异。胰岛素对葡萄糖转化为中性甘油酯的刺激作用，在取自成熟受试者的每种大小脂肪细胞中与基础速率无显著差异，而在取自生长中受试者的脂肪细胞中，在每种脂肪细胞大小类别中与基础速率均有显著差异。这些结果表明，考虑脂肪细胞大小时，不仅生长中受试者基础状态下葡萄糖转化为中性甘油酯的速率更高，而且其对外源性胰岛素的反应性也更高，并且先前报道的大脂肪细胞的胰岛素不敏感性可能受年龄影响。
