新生期诱导耐受的大鼠对外来移植抗原的主要组织相容性复合体（MHC）限制

Major histocompatibility complex (MHC) restriction of foreign transplantation antigens in rats rendered tolerant at birth.

作者信息

Kimura H, Desquenne-Clark L, Miyamoto M, Silvers W K

出版信息

J Exp Med. 1986 Dec 1;164(6):2031-7. doi: 10.1084/jem.164.6.2031.

DOI:10.1084/jem.164.6.2031

PMID:3537194

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188485/

Abstract

Evidence is presented that MHC restriction of foreign transplantation antigens occurs when tolerance is induced. Whereas PVG and F344 rats rendered tolerant at birth with (DA X PVG)F1 and (DA X F344)F1 hybrid bone marrow cells (BMC), respectively, accept ACI skin grafts, presumably because the foreign transplantation antigens of these third party grafts, which are MHC-compatible with DA, are recognized only in association with the MHC of the hosts, DA rats rendered tolerant with (DA X PVG)F1 or (DA X F344)F1 hybrid BMC usually reject ACI skin. Further support that MHC restriction accompanies the induction of tolerance is provided by the observation that Lewis.1N rats rendered tolerant at birth with athymic (nude) Wag BMC are much more likely to accept BN.B2 (MHC-compatible with Wag) skin grafts, than BN (MHC-compatible with Lewis.1N) grafts.

摘要

有证据表明，在诱导耐受时会出现对外源移植抗原的MHC限制。分别用（DA×PVG）F1和（DA×F344）F1杂交骨髓细胞（BMC）在出生时诱导耐受的PVG和F344大鼠接受ACI皮肤移植，推测是因为这些与DA MHC相容的第三方移植物的外源移植抗原仅在与宿主DA的MHC相关联时才被识别，用（DA×PVG）F1或（DA×F344）F1杂交BMC诱导耐受的DA大鼠通常会排斥ACI皮肤。Lewis.1N大鼠在出生时用无胸腺（裸）Wag BMC诱导耐受，与接受BN（与Lewis.1N MHC相容）移植物相比，它们更有可能接受BN.B2（与Wag MHC相容）皮肤移植，这一观察结果进一步支持了MHC限制伴随耐受诱导的观点。