Silvers W K, Collins N H, Naji M
J Exp Med. 1983 Feb 1;157(2):591-9. doi: 10.1084/jem.157.2.591.
The attributes of the test grafts with which putatively tolerant rats are challenged influence their immune response. Lewis (Lew) rats inoculated at birth with Lew/BN F1 hybrid bone marrow cells accept large skin allografts more readily than small allografts, and F1 hybrid skin grafts survive better than BN transplants. The results indicate that the survivals of these major histocompatibility complex-incompatible grafts are determined by the same factors that operate when only weak histoincompatibilities prevail.
用于挑战假定耐受大鼠的测试移植物的属性会影响它们的免疫反应。出生时接种了Lew/BN F1杂交骨髓细胞的Lewis(Lew)大鼠比小的同种异体移植物更容易接受大的皮肤同种异体移植物,并且F1杂交皮肤移植物比BN移植物存活得更好。结果表明,这些主要组织相容性复合体不相容移植物的存活是由仅存在弱组织不相容性时起作用的相同因素决定的。