帕金森病左旋多巴长期治疗期间出现的问题：对治疗反应的变化
Problems arising during chronic treatment with L-dopa for Parkinson's disease: changes in response to treatment.
作者信息
Caraceni T A, Girotti F, Giovannini P, Parati E
出版信息
J Neural Transm Suppl. 1986;22:189-99.
Some aspects of the problems of long-term L-dopa treatment syndrome are reviewed, with special attention to the changes in response to treatment with dopaminergic agents, specifically end-of-dose deterioration, the on-off phenomenon and hyperkinesia. The various hypotheses for interpreting these are presented, with particular stress on changes in the function of DA-ergic receptors. It is concluded that the on-off phenomenon is probably related to changes in plasma L-dopa levels and to decreased stores of intraneural dopamine.
本文综述了长期左旋多巴治疗综合征问题的某些方面，特别关注对多巴胺能药物治疗反应的变化，具体包括剂末恶化、开关现象和运动障碍。文中提出了解释这些现象的各种假说，特别强调了多巴胺能受体功能的变化。得出的结论是，开关现象可能与血浆左旋多巴水平的变化以及神经内多巴胺储备的减少有关。
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