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Striatal dopaminoceptive system changes and motor response complications in L-dopa-treated patients with advanced Parkinson's disease.

作者信息

Chase T N, Engber T M, Mouradian M M

机构信息

Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.

出版信息

Adv Neurol. 1993;60:181-5.

PMID:8420133
Abstract
摘要

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Striatal dopaminoceptive system changes and motor response complications in L-dopa-treated patients with advanced Parkinson's disease.左旋多巴治疗的晚期帕金森病患者纹状体多巴胺感受系统变化及运动反应并发症
Adv Neurol. 1993;60:181-5.
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De novo administration of ropinirole and bromocriptine induces less dyskinesia than L-dopa in the MPTP-treated marmoset.在经MPTP处理的狨猴中,与左旋多巴相比,罗匹尼罗和溴隐亭的从头给药诱导的运动障碍较少。
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Levodopa-induced dyskinesias in Parkinson's disease phenomenology and pathophysiology.帕金森病中左旋多巴诱发的异动症:现象学与病理生理学
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Problems arising during chronic treatment with L-dopa for Parkinson's disease: changes in response to treatment.帕金森病左旋多巴长期治疗期间出现的问题:对治疗反应的变化
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The monoamine reuptake inhibitor BTS 74 398 fails to evoke established dyskinesia but does not synergise with levodopa in MPTP-treated primates.单胺再摄取抑制剂BTS 74 398未能诱发已有的运动障碍,但在经MPTP处理的灵长类动物中,它与左旋多巴没有协同作用。
Mov Disord. 2004 Jan;19(1):15-21. doi: 10.1002/mds.10596.
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Effect of adding the D1 agonist CY 208-243 to chronic bromocriptine treatment. I: Evaluation of motor parameters in relation to striatal catecholamine content and dopamine receptors.在慢性溴隐亭治疗中添加D1激动剂CY 208-243的效果。I:与纹状体儿茶酚胺含量和多巴胺受体相关的运动参数评估。
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Wearing-off fluctuations in Parkinson's disease: contribution of postsynaptic mechanisms.帕金森病中的剂末现象波动:突触后机制的作用
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Is the decreasing responsiveness of axial motor symptoms to L-dopa in elderly parkinsonian patients related to age-associated nonparkinsonian pathologies?老年帕金森病患者中轴性运动症状对左旋多巴的反应性降低是否与年龄相关的非帕金森病病理改变有关?
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Motor response complications and the function of striatal efferent systems.运动反应并发症与纹状体传出系统的功能
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Cerebral uptake and utilization of therapeutic [beta-11C]-L-DOPA in Parkinson's disease measured by positron emission tomography. Relations to motor response.帕金森病中通过正电子发射断层扫描测量治疗性[β-11C]-L-多巴的脑摄取和利用。与运动反应的关系。
Acta Neurol Scand. 1992 Feb;85(2):95-102. doi: 10.1111/j.1600-0404.1992.tb04005.x.

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L-Dihydroxyphenylalanine modulates the steady-state expression of mouse striatal tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine and its metabolites in an MPTP mouse model of Parkinson's disease.L-二羟苯丙氨酸调节 MPTP 帕金森病小鼠模型中鼠纹状体酪氨酸羟化酶、芳香族 L-氨基酸脱羧酶、多巴胺及其代谢物的稳态表达。
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Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys.
局部纹状体多巴胺可能会增强帕金森病猴的运动障碍。
Exp Neurol. 2006 Feb;197(2):363-72. doi: 10.1016/j.expneurol.2005.10.022. Epub 2005 Dec 9.
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Administration of FGF-1 through transfected cells alleviates MPTP toxicity in mice.通过转染细胞给予FGF-1可减轻小鼠的MPTP毒性。
Neurotox Res. 2001 Jul;3(3):249-53. doi: 10.1007/BF03033263.