Department of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria.
Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Front Cell Infect Microbiol. 2022 Mar 15;12:860163. doi: 10.3389/fcimb.2022.860163. eCollection 2022.
We describe the identification of a methicillin-resistant, high-level mupirocin-resistant . The isolate (1801221) was characterized as t6675-ST2250-SCCIVc, and whole-genome sequencing revealed that the isolate possessed two plasmids. One plasmid (34,870 bp), designated p1_1801221 with , harboured the mupirocin resistance () gene. The second plasmid (20,644 bp), assigned as p2_1801221 with and , carried the resistance determinants for penicillin () and cadmium (). Phylogenetic analysis revealed that the isolate clustered with the European ST2250 lineage. The overall high similarity of both plasmids in with published DNA sequences of plasmids strongly suggests an interspecies transfer. The pathogenic potential, community and nosocomial spread, and acquisition of antibiotic resistance gene determinants, including the gene by , highlight its clinical significance and the need for its correct identification.
我们描述了一种耐甲氧西林、高水平米诺环素耐药的 的鉴定。该分离株（1801221）被鉴定为 t6675-ST2250-SCCIVc，全基因组测序显示该分离株携带两个质粒。一个质粒（34870bp），命名为 p1_1801221，具有 ，携带米诺环素耐药（）基因。第二个质粒（20644bp），指定为 p2_1801221，具有 和 ，携带青霉素（）和镉（）耐药决定因子。系统发育分析显示，该分离株与欧洲 ST2250 谱系聚类。两个质粒在 中的高度相似性与已发表的 质粒 DNA 序列非常相似，强烈提示种间转移。其临床意义以及对其正确鉴定的必要性，包括 基因的获得，突出了其致病性、社区和医院传播以及抗生素耐药基因决定因子的潜在危害。
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