Udo E E, Pearman J W, Grubb W B
School of Biomedical Sciences, Curtin University of Technology, Perth, Western Australia.
J Hosp Infect. 1994 Mar;26(3):157-65. doi: 10.1016/0195-6701(94)90038-8.
Six mupirocin-resistant Staphylococcus aureus were isolated from patients living in the northern part of Western Australia (WA). They were all resistant to methicillin, tetracycline, trimethoprim and cadmium and harboured similar 41.4 kb plasmids. Transfer and curing experiments with one of the isolates, WBG7569, demonstrated that the 41.4 kb plasmid encoded resistance to mupirocin, tetracycline, trimethoprim and cadmium. The isolates were compared by pulsed-field gel electrophoresis with methicillin-resistant S. aureus (MRSA) previously isolated from the Kimberley region in the northern-most part of WA (WA MRSA). The mupirocin-resistant isolates were found to be closely related to WA MRSA suggesting that they were WA MRSA which had acquired a new multiple-resistance plasmid encoding high-level mupirocin resistance.
从西澳大利亚州（WA）北部地区的患者中分离出6株耐莫匹罗星金黄色葡萄球菌。它们对甲氧西林、四环素、甲氧苄啶和镉均耐药，并携带相似的41.4 kb质粒。对其中一株分离株WBG7569进行的转移和消除实验表明，41.4 kb质粒编码对莫匹罗星、四环素、甲氧苄啶和镉的耐药性。通过脉冲场凝胶电泳将这些分离株与先前从WA最北部的金伯利地区分离出的耐甲氧西林金黄色葡萄球菌（WA MRSA）进行比较。发现耐莫匹罗星分离株与WA MRSA密切相关，这表明它们是获得了一个编码高水平莫匹罗星耐药性的新的多重耐药质粒的WA MRSA。
