• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于网络药理学探讨三七治疗心肌纤维化的作用机制。

Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis.

机构信息

Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China.

Heilongjiang Academy of Chinese Medical Sciences, Harbin 150036, China.

出版信息

J Diabetes Res. 2022 Mar 25;2022:8895950. doi: 10.1155/2022/8895950. eCollection 2022.

DOI:10.1155/2022/8895950
PMID:35372585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8975676/
Abstract

OBJECTIVE

The mechanism of Panax notoginseng in treating myocardial fibrosis (MF) was investigated using network pharmacology.

METHODS

Effective ingredients and potential targets of Panax notoginseng were screened in relevant databases to construct a compound-target network. Targets of MF were then screened to select common targets and construct a protein-protein interaction network. This was followed by Gene Ontology and pathway enrichment analyses. Molecular docking then verified the results of network analysis.

RESULTS

A total of 14 effective ingredients and 119 potential targets for MF were predicted. Quercetin, beta-sitosterol, and gossypetin were speculated to be the main active ingredients. The mechanism of action may be related to AGE-RAGE, proteoglycans, and IL-17 signaling pathways. Five key targets (IL6, ALB, AKT1, TNF, and VEGFA) may be involved in the treatment of MF using Panax notoginseng.

CONCLUSIONS

This study embodies the complex network relationship of multicomponents, multitargets, and multipathways of Panax notoginseng in treating MF and provides a novel method for further research on this herb's mechanism.

摘要

目的

采用网络药理学研究三七治疗心肌纤维化（MF）的作用机制。

方法

在相关数据库中筛选三七的有效成分和潜在靶点，构建化合物-靶点网络。然后筛选 MF 的靶点，选择共同靶点并构建蛋白质-蛋白质相互作用网络。接着进行基因本体和通路富集分析。最后通过分子对接验证网络分析的结果。

结果

共预测到 14 种有效成分和 119 个 MF 的潜在靶点。槲皮素、β-谷甾醇和棉子苷可能是主要的活性成分。作用机制可能与 AGE-RAGE、蛋白聚糖和 IL-17 信号通路有关。五个关键靶点（IL6、ALB、AKT1、TNF 和 VEGFA）可能参与了三七治疗 MF。

结论

本研究体现了三七多成分、多靶点、多途径治疗 MF 的复杂网络关系，为进一步研究该药物的作用机制提供了一种新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/51946df41542/JDR2022-8895950.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/4a59d6a1a064/JDR2022-8895950.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/1c0fa325ba05/JDR2022-8895950.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/39898fe35121/JDR2022-8895950.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/710f146bc944/JDR2022-8895950.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/8572b178dafa/JDR2022-8895950.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/259bf0c9e8ef/JDR2022-8895950.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/51946df41542/JDR2022-8895950.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/4a59d6a1a064/JDR2022-8895950.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/1c0fa325ba05/JDR2022-8895950.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/39898fe35121/JDR2022-8895950.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/710f146bc944/JDR2022-8895950.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/8572b178dafa/JDR2022-8895950.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/259bf0c9e8ef/JDR2022-8895950.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a300/8975676/51946df41542/JDR2022-8895950.007.jpg

相似文献

1
Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis.基于网络药理学探讨三七治疗心肌纤维化的作用机制。
J Diabetes Res. 2022 Mar 25;2022:8895950. doi: 10.1155/2022/8895950. eCollection 2022.
2
Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy.基于网络药理学的三七治疗糖尿病视网膜病变的作用机制研究。
Comb Chem High Throughput Screen. 2020;23(4):334-344. doi: 10.2174/1386207323666200305093709.
3
[Mechanism of Panax notoginseng saponins in treating diabetic kidney disease based on network pharmacology and experimental verification].基于网络药理学和实验验证的三七总皂苷治疗糖尿病肾病的机制研究
Zhongguo Zhong Yao Za Zhi. 2024 Sep;49(17):4607-4616. doi: 10.19540/j.cnki.cjcmm.20240516.701.
4
Using Network Pharmacology to Explore the Mechanism of Peach Kernel-Safflower in the Treatment of Diabetic Nephropathy.基于网络药理学探讨桃仁-红花治疗糖尿病肾病的作用机制。
Biomed Res Int. 2021 Feb 1;2021:6642584. doi: 10.1155/2021/6642584. eCollection 2021.
5
Homotherapy for heteropathy of Alzheimer's disease and anemia through reducing the expression of toll-like receptor and TNF by steamed Panax notoginseng.三七蒸制通过降低 Toll 样受体和 TNF 的表达对阿尔茨海默病和贫血的异病同治作用
Biomed Pharmacother. 2023 Sep;165:115075. doi: 10.1016/j.biopha.2023.115075. Epub 2023 Jun 28.
6
[Mechanism of Carthami Flos and Lepidii Semen drug pair in inhibition of myocardial fibrosis by improving cardiac microenvironment based on network pharmacology and animal experiment].基于网络药理学和动物实验探讨红花与葶苈子药对通过改善心脏微环境抑制心肌纤维化的机制
Zhongguo Zhong Yao Za Zhi. 2022 Feb;47(3):753-763. doi: 10.19540/j.cnki.cjcmm.20210929.401.
7
Exploration of the Mechanism of Tripterygium Wilfordii in the Treatment of Myocardial Fibrosis Based on Network Pharmacology and Molecular Docking.基于网络药理学和分子对接技术探讨雷公藤治疗心肌纤维化的作用机制。
Curr Comput Aided Drug Des. 2023;19(1):68-79. doi: 10.2174/1573409919666221028120329.
8
Integrating Network Pharmacology and Experimental Verification to Explore the Targets and Mechanism for Panax Notoginseng Saponins against Coronary In-stent Restenosis.运用网络药理学与实验验证相结合的方法探索三七总皂苷抗冠状动脉支架内再狭窄的作用靶点及机制。
Curr Pharm Des. 2023;29(28):2239-2257. doi: 10.2174/0113816128255082230920071237.
9
Integrated RNA-sequencing and network pharmacology approach reveals the protection of Yiqi Huoxue formula against idiopathic pulmonary fibrosis by interfering with core transcription factors.基于 RNA 测序和网络药理学的整合分析揭示了益气活血方通过干预核心转录因子防治特发性肺纤维化的作用机制。
Phytomedicine. 2022 Sep;104:154301. doi: 10.1016/j.phymed.2022.154301. Epub 2022 Jun 29.
10
Network Pharmacology-Based and Molecular Docking-Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson's Disease with Sleep Disorder.基于网络药理学和分子对接的酸枣仁汤治疗伴有睡眠障碍的帕金森病的分析。
Biomed Res Int. 2021 Oct 8;2021:1752570. doi: 10.1155/2021/1752570. eCollection 2021.

引用本文的文献

1
Integrated analyses to explore the mechanism of Gancao Renshen Zhixue Decoction in treating liver cirrhosis.综合分析探讨甘草人参止血汤治疗肝硬化的机制。
Sci Rep. 2025 Jul 2;15(1):23496. doi: 10.1038/s41598-025-09206-5.
2
L. protects against renal function decline in a mouse model of type 2 diabetic nephropathy by modulating the PI3K-Akt-ERK signaling pathway.L通过调节PI3K-Akt-ERK信号通路，在2型糖尿病肾病小鼠模型中保护肾脏功能免于衰退。
Front Pharmacol. 2025 Mar 18;16:1566723. doi: 10.3389/fphar.2025.1566723. eCollection 2025.
3
Effect and mechanism of Sanqi () in treating periodontitis.

本文引用的文献

1
Pathophysiology of cardiovascular disease in diabetes mellitus.糖尿病中心血管疾病的病理生理学
Cardiovasc Endocrinol Metab. 2018 Feb 14;7(1):4-9. doi: 10.1097/XCE.0000000000000141. eCollection 2018 Mar.
2
Ginsenoside Rb1 ameliorates CKD-associated vascular calcification by inhibiting the Wnt/β-catenin pathway.人参皂苷 Rb1 通过抑制 Wnt/β-catenin 通路改善 CKD 相关血管钙化。
J Cell Mol Med. 2019 Oct;23(10):7088-7098. doi: 10.1111/jcmm.14611. Epub 2019 Aug 19.
3
Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases.
三七治疗牙周炎的作用及机制。 （注：括号里的“()”原文缺失内容，这里按字面保留）
J Tradit Chin Med. 2025 Feb;45(1):66-75. doi: 10.19852/j.cnki.jtcm.20241111.001.
4
AGE-RAGE Axis and Cardiovascular Diseases: Pathophysiologic Mechanisms and Prospects for Clinical Applications.衰老-晚期糖基化终末产物受体轴与心血管疾病：病理生理机制及临床应用前景
Cardiovasc Drugs Ther. 2024 Nov 5. doi: 10.1007/s10557-024-07639-0.
5
Protective Effect and Related Mechanism of Modified Danggui Buxue Decoction on Retinal Oxidative Damage in Mice based on Network Pharmacology.基于网络药理学的加味当归补血汤对小鼠视网膜氧化损伤的保护作用及相关机制。
Curr Pharm Des. 2024;30(24):1912-1926. doi: 10.2174/0113816128293824240517113238.
6
Network pharmacology, molecular docking, and molecular dynamics simulation analysis reveal the molecular mechanism of halociline against gastric cancer.网络药理学、分子对接和分子动力学模拟分析揭示了卤西立明抗胃癌的分子机制。
Mol Divers. 2024 Mar 19. doi: 10.1007/s11030-024-10822-y.
7
Integrating Network Pharmacology and In Vitro Experimental Verification Revealing Bushenhuoxue Recipe Against Intrauterine Adhesions via PI3K-AKT Signaling Pathway.整合网络药理学与体外实验验证揭示补肾活血方通过PI3K-AKT信号通路治疗宫腔粘连的机制
Biochem Genet. 2025 Feb;63(1):686-697. doi: 10.1007/s10528-024-10732-6. Epub 2024 Mar 19.
8
Quercetin-crosslinked chitosan nanoparticles: a potential treatment for allergic rhinitis.槲皮素交联壳聚糖纳米粒：治疗过敏性鼻炎的一种潜在方法。
Sci Rep. 2024 Feb 18;14(1):4021. doi: 10.1038/s41598-024-54501-2.
9
Traditional Chinese Medicine-based Treatment in Cardiovascular Disease: Potential Mechanisms of Action.基于中医药的心血管病治疗：作用机制探讨。
Curr Pharm Biotechnol. 2024;25(17):2186-2199. doi: 10.2174/0113892010279151240116103917.
10
Erzhiwan Ameliorates Restraint Stress- and Monobenzone-Induced Depigmentation in Mice by Inhibiting Macrophage Migration Inhibitory Factor and 8-Hydroxy-2-Deoxyguanosine.二至丸通过抑制巨噬细胞移动抑制因子和8-羟基-2'-脱氧鸟苷改善小鼠束缚应激和单苯醚诱导的色素脱失。
Clin Cosmet Investig Dermatol. 2024 Jan 22;17:147-158. doi: 10.2147/CCID.S420385. eCollection 2024.
维生素 D 在 AGE/RAGE 相关心血管疾病中的治疗潜力。
Cell Mol Life Sci. 2019 Oct;76(20):4103-4115. doi: 10.1007/s00018-019-03204-3. Epub 2019 Jun 27.
4
Cardiac fibrosis - A short review of causes and therapeutic strategies.心肌纤维化——病因和治疗策略简述。
Adv Drug Deliv Rev. 2019 Jun;146:77-82. doi: 10.1016/j.addr.2019.05.011. Epub 2019 May 31.
5
Hypoalbuminemia is a frequent marker of increased mortality in cardiogenic shock.低蛋白血症是心源性休克患者死亡率升高的一个常见标志物。
PLoS One. 2019 May 16;14(5):e0217006. doi: 10.1371/journal.pone.0217006. eCollection 2019.
6
Potential Effects of CXCL9 and CCL20 on Cardiac Fibrosis in Patients with Myocardial Infarction and Isoproterenol-Treated Rats.CXCL9和CCL20对心肌梗死患者及异丙肾上腺素处理大鼠心脏纤维化的潜在影响
J Clin Med. 2019 May 11;8(5):659. doi: 10.3390/jcm8050659.
7
Interleukin-17 pathways in systemic sclerosis-associated fibrosis.白细胞介素-17 通路在系统性硬皮病相关纤维化中的作用。
Rheumatol Int. 2019 Jul;39(7):1135-1143. doi: 10.1007/s00296-019-04317-5. Epub 2019 May 9.
8
Stemona alkaloids suppress the positive feedback loop between M2 polarization and fibroblast differentiation by inhibiting JAK2/STAT3 pathway in fibroblasts and CXCR4/PIK/AKT1 pathway in macrophages.石蒜生物碱通过抑制成纤维细胞中的 JAK2/STAT3 通路和巨噬细胞中的 CXCR4/PI3K/AKT1 通路，抑制 M2 极化和纤维化细胞分化之间的正反馈环。
Int Immunopharmacol. 2019 Jul;72:385-394. doi: 10.1016/j.intimp.2019.04.030. Epub 2019 Apr 24.
9
Ginsenoside Rb1 protects cardiomyocytes from oxygen-glucose deprivation injuries by targeting microRNA-21.人参皂苷Rb1通过靶向微小RNA-21保护心肌细胞免受氧糖剥夺损伤。
Exp Ther Med. 2019 May;17(5):3709-3716. doi: 10.3892/etm.2019.7330. Epub 2019 Mar 1.
10
Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts.心肌细胞在面对纤维化条件时会重新表达细胞外基质的转录本。
Acta Biomater. 2019 Apr 15;89:180-192. doi: 10.1016/j.actbio.2019.03.017. Epub 2019 Mar 9.