Rodriguez-Araujo Gerardo, Nakagami Hironori
Clinical Research Innovation, ProSciento Inc., Chula Vista, California.
Graduate School, University of Arkansas for Medical Science, Little Rock, Arkansas, USA.
Cardiovasc Endocrinol Metab. 2018 Feb 14;7(1):4-9. doi: 10.1097/XCE.0000000000000141. eCollection 2018 Mar.
Diabetes mellitus elicits cellular, epigenetic, and post-translational changes that directly or indirectly affect the biology of the vasculature and other metabolic systems resulting in the apparition of cardiovascular disease. In this review, we provide a current perspective on the most recent discoveries in this field, with particular focus on hyperglycemia- induced pathology in the cardiovascular system. We also provide perspective on the clinical importance of molecular targeting of cardiovascular and diabetes mellitus therapies to treat hyperglycemia, inflammation, thrombosis, dyslipidemia, atherosclerosis, and hypertension.
糖尿病引发细胞、表观遗传和翻译后变化，这些变化直接或间接影响血管系统和其他代谢系统的生物学特性，从而导致心血管疾病的出现。在本综述中，我们提供了该领域最新发现的当前观点，特别关注心血管系统中高血糖诱导的病理变化。我们还提供了关于心血管和糖尿病治疗分子靶向治疗高血糖、炎症、血栓形成、血脂异常、动脉粥样硬化和高血压的临床重要性的观点。
