Ogilvie A L, Atkinson M
J R Soc Med. 1986 Oct;79(10):584-7. doi: 10.1177/014107688607901009.
Dimethicone is a common additive to antacids, although its value in the treatment of reflux oesophagitis is unproven. Its efficacy was assessed by comparing the effect of a dimethicone-containing antacid gel (Asilone Gel) with a simple antacid gel in a double-blind trial in 45 patients with reflux oesophagitis. Thirty-eight patients completed the eight-week course of therapy. Antacid therapy alone resulted in a significant improvement of both symptoms and oesophagitis in gastro-oesophageal reflux. The inclusion of dimethicone in the antacid gel preparation did not confer any benefit in terms of symptomatic assessment but did confer a small advantage with regard to objective markers of oesophageal inflammation, suggesting that a dimethicone-containing antacid is of value in the treatment of symptomatic gastro-oesophageal reflux.
二甲硅油是抗酸剂中常用的添加剂，尽管其在治疗反流性食管炎方面的价值尚未得到证实。在一项针对45例反流性食管炎患者的双盲试验中，通过比较含二甲硅油的抗酸凝胶（阿西隆凝胶）与单纯抗酸凝胶的效果来评估其疗效。38例患者完成了为期8周的治疗疗程。单纯抗酸治疗使胃食管反流的症状和食管炎均有显著改善。抗酸凝胶制剂中加入二甲硅油在症状评估方面未带来任何益处，但在食管炎症的客观指标方面有小的优势，这表明含二甲硅油的抗酸剂在治疗有症状的胃食管反流方面具有价值。
