Hine K R, Holmes G K, Melikian V, Lucey M, Fairclough P D
Digestion. 1984;29(2):119-23. doi: 10.1159/000199020.
This study was designed to assess the effect of ranitidine on patients with symptomatic oesophageal reflux. In a double-blind comparative trial in 46 patients a twice daily dose of 150 mg ranitidine was compared with placebo. Relief of pain, endoscopic healing and histological improvement were significantly better in those treated with ranitidine. Thus, ranitidine is of value in the management of patients with reflux oesophagitis and may prevent the development of peptic stricture.
本研究旨在评估雷尼替丁对有症状的食管反流患者的疗效。在一项针对46例患者的双盲对照试验中，将每日两次服用150毫克雷尼替丁的剂量与安慰剂进行了比较。接受雷尼替丁治疗的患者在疼痛缓解、内镜下愈合和组织学改善方面明显更好。因此，雷尼替丁在反流性食管炎患者的治疗中具有价值，并且可能预防消化性狭窄的发生。
