“按方案”实施儿童肿瘤学组试验的实践模式在放射肿瘤学界内。
"Per protocol" practice patterns for Children's Oncology Group trials within the radiation oncology community.
机构信息
Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Department of Radiation Oncology and Molecular Radiation Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
出版信息
Pediatr Blood Cancer. 2023 Aug;70(8):e29673. doi: 10.1002/pbc.29673. Epub 2022 Apr 4.
Little is known about the prevalence of pediatric radiation oncologists treating patients off study according to Children's Oncology Group (COG) trials before data are available regarding toxicity and efficacy of novel radiotherapy regimens. We conducted a 12-question survey of 358 pediatric radiation oncologists to characterize practice patterns regarding ongoing and completed COG protocols off study. With 130 responses (40.3%), the prevalence of providing treatment per protocol, but off study, before data are available in abstract or peer-reviewed form varied from 9.1% (for ACNS1422) to 88.1% (for AHOD1331). Future studies are needed to understand the effects of these practice patterns on outcomes.
关于在新型放射治疗方案的毒性和疗效数据可用之前，儿科肿瘤学家根据儿童肿瘤学组（COG）试验对研究外的患者进行治疗的流行情况知之甚少。我们对 358 名儿科肿瘤学家进行了一项包含 12 个问题的调查，以描述有关正在进行和已完成的 COG 方案的研究外实践模式。在摘要或同行评审形式的数据可用之前，根据协议但研究外进行治疗的比例为 130 次（40.3%），从 9.1%（ACNS1422）到 88.1%（AHOD1331）不等。需要进一步的研究来了解这些实践模式对结果的影响。
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