Department of Medicine, 22165University of Arizona Medical Center - University Campus, Tucson, AZ, USA.
Department of Immunology, College of Medicine, 242724University of Arizona, Tucson, AZ, USA.
Int J STD AIDS. 2022 May;33(6):597-603. doi: 10.1177/09564624221091455. Epub 2022 Apr 4.
It has been hypothesized that HIV-1 infection prematurely "ages" individuals phenotypically and immunologically. We measured phenotypic frailty and immune "aging" markers on T-cells of people living with HIV on long term, suppressive anti-retroviral therapy (ART) to determine if there is an association between frailty and immunosenescence.
Thirty-seven (37) community-dwelling people living with HIV were measured for frailty using a sensor-based frailty meter that quantifies weakness, slowness, rigidity, and exhaustion. An immunological profile of the patients' CD4 and CD8 T-cell expression of cell surface proteins and cytokines was performed ( = 20).
Phenotypic frailty prevalence was 19% (7/37) and correlated weakly with the number of past medical events accrued by the patient (r = 0.34, = .04). There was no correlation of frailty with age, sex, prior AIDS diagnosis or HIV-1 viral load, or IFN-γ expression by CD4 or CD8 T-cells. There were more immune competent (CD28 CD57) cells than exhausted/senescent (CD28 CD57) T cells.
Frailty in people living with HIV on long term, suppressive ART did not correlate with aging or T cell markers of exhaustion or immunosenescence.
有人假设 HIV-1 感染会使个体在表型和免疫上过早“衰老”。我们在长期接受抑制性抗逆转录病毒治疗（ART）的 HIV 感染者的 T 细胞上测量了表型脆弱性和免疫“衰老”标志物，以确定脆弱性与免疫衰老之间是否存在关联。
使用基于传感器的脆弱性计测量了 37 名居住在社区中的 HIV 感染者的脆弱性，该计可量化虚弱、缓慢、僵硬和疲惫。对患者的 CD4 和 CD8 T 细胞的细胞表面蛋白和细胞因子表达进行了免疫分析（n = 20）。
表型脆弱性的患病率为 19%（7/37），与患者过去积累的医疗事件数量呈弱相关（r = 0.34，p =.04）。脆弱性与年龄、性别、既往 AIDS 诊断或 HIV-1 病毒载量、或 CD4 或 CD8 T 细胞的 IFN-γ表达均无相关性。具有免疫功能的（CD28 CD57）细胞比衰竭/衰老的（CD28 CD57）T 细胞多。
长期接受抑制性 ART 的 HIV 感染者的脆弱性与衰老或 T 细胞衰竭或免疫衰老的标志物无关。
