Department of Clinical Neuroscience, Neuro, Karolinska Institute.
Centrum for Neurology, Academic Specialist Centrum, Region Stockholm.
Neuropsychology. 2022 Mar;36(3):206-215. doi: 10.1037/neu0000794.
Parkinson's disease (PD) is a neurodegenerative disorder which can substantially affect nonmotor functions related to emotional processing. We aimed to examine the underlying differences in emotional processing in PD by comparing how early-stage PD patients recognize, rate, and react to facial, bodily, and vocal emotional stimuli to that of healthy controls (HC).
We compared emotion recognition, emotional rating bias, and emotional response range between a PD patient group (n = 33) and a HC group (n = 29). Pearson's correlations were conducted to evaluate the relationship between emotion processing measures and clinical outcome measures in each group.
PD patients showed an enhanced emotion processing as compared to HC. They were overall more accurate than HC's at identifying correct emotions and furthermore showed an increase in emotional ratings and reactions to both positive and negative stimuli that scaled with increased symptom severity, thereby yielding significant correlations between clinical outcomes and emotional range in the PD patient group.
Our results suggest that alterations in emotional processing reflect disease progression in early PD. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
帕金森病（PD）是一种神经退行性疾病，可严重影响与情绪处理相关的非运动功能。我们旨在通过比较早期 PD 患者识别、评估和对面部、身体和声音情绪刺激的反应与健康对照组（HC）之间的差异，来研究情绪处理的潜在差异。
我们比较了 PD 患者组（n=33）和 HC 组（n=29）之间的情绪识别、情绪评分偏差和情绪反应范围。在每组中，进行 Pearson 相关性分析以评估情绪处理测量值与临床结果测量值之间的关系。
与 HC 相比，PD 患者表现出增强的情绪处理能力。他们在识别正确情绪方面总体上比 HC 更准确，并且对正性和负性刺激的情绪评分和反应增加，与症状严重程度增加相关，从而在 PD 患者组中产生了临床结果和情绪范围之间的显著相关性。
我们的研究结果表明，情绪处理的改变反映了早期 PD 中的疾病进展。
