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"Stick a Fork in Me; I'm Done": Epithelial Cell Expression of ORMDL Sphingolipid Biosynthesis Regulator 3 Mediates Autophagic Cell Death.

作者信息

Curtiss Miranda L, Deshane Jessy S

机构信息

Department of Medicine, Division of Pulmonary Allergy and Critical Care Medicine University of Alabama at Birmingham Birmingham, Alabama.

出版信息

Am J Respir Cell Mol Biol. 2022 Jun;66(6):593-595. doi: 10.1165/rcmb.2022-0023ED.

DOI:10.1165/rcmb.2022-0023ED
PMID:35377833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9163635/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/9163635/3899f44717e3/rcmb.2022-0023EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/9163635/3899f44717e3/rcmb.2022-0023EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/9163635/3899f44717e3/rcmb.2022-0023EDf1.jpg

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"Stick a Fork in Me; I'm Done": Epithelial Cell Expression of ORMDL Sphingolipid Biosynthesis Regulator 3 Mediates Autophagic Cell Death.“用叉子戳我吧，我不行了”：ORMDL鞘脂生物合成调节因子3的上皮细胞表达介导自噬性细胞死亡
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ORMDL mislocalization by impaired autophagy in Niemann-Pick type C disease leads to increased de novo sphingolipid biosynthesis.ORMDL 蛋白在尼曼-匹克 C 型疾病中通过受损的自噬作用发生易位，导致从头合成鞘脂增加。
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Asthma Susceptibility Gene Promotes Autophagy in Human Bronchial Epithelium.哮喘易感性基因促进人支气管上皮细胞自噬。
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ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.ORMDL/丝氨酸棕榈酰转移酶化学计量决定ORMDL3表达对鞘脂生物合成的影响。
J Lipid Res. 2015 Apr;56(4):898-908. doi: 10.1194/jlr.M057539. Epub 2015 Feb 17.
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The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma.ORMDL 蛋白在细胞神经鞘脂中的作用与哮喘
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Transmembrane topology of mammalian ORMDL proteins in the endoplasmic reticulum as revealed by the substituted cysteine accessibility method (SCAM™).哺乳动物 ORMDL 蛋白在 ER 中的跨膜拓扑结构，通过取代半胱氨酸可及性方法（SCAM™）揭示。
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Sphingolipids and Asthma.鞘脂类和哮喘。
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CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism.CRISPR/Cas9 敲除 ORMDLs 揭示了神经酰胺代谢的复杂性。
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Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis.哺乳动物 ORMDL 蛋白在神经酰胺生物合成的反馈反应中起介导作用。
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The ORMDL/Orm-serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes.ORMDL/Orm 丝氨酸棕榈酰转移酶（SPT）复合物受神经酰胺直接调节：在分离的膜中重建 SPT 调节。
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Non-apoptotic programmed cell deaths in diabetic pulmonary dysfunction: the new side of advanced glycation end products.糖尿病性肺功能障碍中的非凋亡程序性细胞死亡：晚期糖基化终产物的新作用。
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本文引用的文献

1
Asthma Susceptibility Gene Promotes Autophagy in Human Bronchial Epithelium.哮喘易感性基因促进人支气管上皮细胞自噬。
Am J Respir Cell Mol Biol. 2022 Jun;66(6):661-670. doi: 10.1165/rcmb.2021-0305OC.
2
Calcium Signaling Regulates Autophagy and Apoptosis.钙信号调节自噬和细胞凋亡。
Cells. 2021 Aug 18;10(8):2125. doi: 10.3390/cells10082125.
3
Diversity and the Splice of Life: Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African American Individuals.多样性与生命的拼接：定位与非裔美国人早发性哮喘相关变异的17q12 - 21.1基因座
Am J Respir Crit Care Med. 2021 Feb 15;203(4):401-403. doi: 10.1164/rccm.202010-3802ED.
4
Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.定位与非裔美国人早发性哮喘相关的 17q12-21.1 位点变异。
Am J Respir Crit Care Med. 2021 Feb 15;203(4):424-436. doi: 10.1164/rccm.202006-2623OC.
5
Decreased sphingolipid synthesis in children with 17q21 asthma-risk genotypes.17q21哮喘风险基因型儿童中鞘脂合成减少。
J Clin Invest. 2020 Feb 3;130(2):921-926. doi: 10.1172/JCI130860.
6
ORMDL3 and allergic asthma: From physiology to pathology.ORMDL3 与过敏性哮喘：从生理学到病理学。
J Allergy Clin Immunol. 2019 Sep;144(3):634-640. doi: 10.1016/j.jaci.2019.07.023. Epub 2019 Jul 31.
7
A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.一项针对 17q12-21 哮喘基因座的十年研究：拼凑谜题。
J Allergy Clin Immunol. 2018 Sep;142(3):749-764.e3. doi: 10.1016/j.jaci.2017.12.974. Epub 2018 Jan 4.
8
The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics.未折叠蛋白反应：在内质网功能与线粒体生物能量学的交叉点上
Front Oncol. 2017 Apr 3;7:55. doi: 10.3389/fonc.2017.00055. eCollection 2017.
9
A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes.一项全基因组范围内对CD4(+)淋巴细胞调节性遗传变异的调查鉴定出了新的哮喘相关基因。
J Allergy Clin Immunol. 2014 Nov;134(5):1153-62. doi: 10.1016/j.jaci.2014.04.011. Epub 2014 Jun 13.
10
ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.ORMDL3 转基因小鼠表现出气道重塑和气道高反应性，这些特征类似于哮喘。
J Immunol. 2014 Apr 15;192(8):3475-87. doi: 10.4049/jimmunol.1303047. Epub 2014 Mar 12.