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快速康复护理程序对腹腔镜直肠癌手术的影响:一项队列比较研究。

Impact of fast-track care program in laparoscopic rectal cancer surgery: a cohort-comparative study.

机构信息

Department of Digestive Surgical Oncology, Institut Paoli Calmettes, 232 Boulevard de Sainte Marguerite, 13009, Marseille, France.

Department of Anesthesiology and Critical Care, Institut Paoli Calmettes, Marseille, France.

出版信息

Surg Endosc. 2022 Jul;36(7):4712-4720. doi: 10.1007/s00464-021-08811-5. Epub 2022 Apr 4.

Abstract

BACKGROUND

Fast-track care programs after surgery improve recovery and decrease the length of hospital stay and postoperative morbidity in colonic cancer. However, the true impact of these programs on morbidity rates after rectal cancer surgery remains unclear. We aimed to assess the feasibility and impact of the fast-track program on postoperative outcomes after restorative laparoscopic rectal cancer resection and temporary loop ileostomy.

METHODS

This single-center observational study assessed data of patients undergoing elective rectal cancer surgery during a defined period before (standard group) and after the introduction of a fast-track program (fast-track group) from a prospectively maintained database. The primary endpoint was postoperative 90-day morbidity. Secondary endpoints were 30-day morbidity, fast-track program compliance, length of hospital stay, and readmission rate.

RESULTS

Overall, 336 patients (n = 176, standard group; n = 160, fast-track group) were assessed; there was no significant between-group difference in the patients' baseline characteristics (age, sex, body mass index, comorbidities, or neoadjuvant treatment). The protocol compliance rate was 91.4% in the fast-track group. The 90-day morbidity and mean total length of hospital stay were significantly lower in the fast-track group than in the standard group (34% vs 49%, respectively, p < 0.01 and 8.96 days vs 10.2 days, p < 0.01, respectively). There was no difference in readmission rates. Multivariate analysis revealed the fast-track program to be the only predictive factor of postoperative morbidity.

CONCLUSION

Fast-track programs can be safely implemented following rectal cancer surgery to reduce the overall morbidity rate and length of hospital stay without adversely increasing the readmission rate.

摘要

背景

手术后的快速康复护理方案可促进结肠直肠癌患者康复,并缩短住院时间和减少术后发病率。然而,这些方案对直肠癌手术后发病率的真正影响尚不清楚。我们旨在评估快速康复护理方案对腹腔镜直肠肿瘤切除和临时回肠造口术后的术后结局的可行性和影响。

方法

这项单中心观察性研究评估了在一个明确的时间段内接受择期直肠肿瘤手术的患者数据,该时间段在引入快速康复护理方案之前(标准组)和之后(快速康复护理组),从一个前瞻性维护的数据库中评估。主要终点是术后 90 天发病率。次要终点是 30 天发病率、快速康复护理方案依从性、住院时间和再入院率。

结果

共有 336 名患者(n=176,标准组;n=160,快速康复护理组)被评估;两组患者的基线特征(年龄、性别、体重指数、合并症或新辅助治疗)无显著差异。快速康复护理组的方案依从率为 91.4%。快速康复护理组的 90 天发病率和平均总住院时间明显低于标准组(分别为 34%和 49%,p<0.01和 8.96 天和 10.2 天,p<0.01)。再入院率无差异。多变量分析显示,快速康复护理方案是术后发病率的唯一预测因素。

结论

快速康复护理方案可安全应用于直肠肿瘤手术后,以降低总体发病率和住院时间,而不会增加再入院率。

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