Department of Imaging, Jiaozhou Central Hospital, Qingdao 266300, China.
Anorectal Department, Rizhao Hospital of TCM, Rizhao 276800, China.
J Healthc Eng. 2022 Mar 26;2022:4147753. doi: 10.1155/2022/4147753. eCollection 2022.
To evaluate the value of the combination of color Doppler ultrasound, computed tomography (CT), and serum tumor marker alpha-fetoprotein (AFP) examination in the diagnosis of hepatocellular carcinoma (HCC).
98 patients with HCC (malignant tumor group) and 50 liver lesion patients (benign control group), were selected for the study, and retrospective statistical methods were used to evaluate the diagnostic values of the three examinations on hepatocellular carcinoma.
(1) When comparing color Doppler ultrasound blood flow parameters, the hepatic artery diameter, peak flow velocity, minimum flow velocity, and resistance index (RI) of hepatocellular carcinoma were significantly higher than those of the benign control group ( < 0.05), while the portal vein flow velocity was significantly lower than that of the control group ( < 0.05). (2) Enhanced CT imaging of hepatocellular carcinoma lesions showed mostly outflow-type enhancement changes, with high- or slightly high-density shadowing and uneven enhancement in the arterial phase, relatively low density and withdrawal of enhancement in the portal vein phase and delayed phase. (3) The serum AFP level of hepatocellular carcinoma patients was significantly higher than that of the benign control group ( < 0.01). (4) The sensitivity of color Doppler ultrasound, CT, and serum AFP alone for the diagnosis of HCC was 79.59%, 85.71%, and 66.33%, and the accuracy was 83.78%, 87.16%, and 74.32%, respectively, while the combination of the three tests could significantly increase the sensitivity to 96.94% and the accuracy to 93.92%, compared with each individual test ( < 0.01).
Color Doppler ultrasound and CT combined with serum AFP examination could significantly improve the sensitivity and accuracy of hepatocellular carcinoma diagnosis, reduce misdiagnosis, and facilitate early diagnosis and clinical early intervention.
评价彩色多普勒超声、计算机断层扫描（CT）和血清肿瘤标志物甲胎蛋白（AFP）联合检查在肝细胞癌（HCC）诊断中的价值。
选择 98 例 HCC 患者（恶性肿瘤组）和 50 例肝病变患者（良性对照组）进行研究，采用回顾性统计方法评估三种检查方法对肝细胞癌的诊断价值。
（1）比较彩色多普勒超声血流参数，肝癌患者肝动脉直径、峰值流速、最小流速、阻力指数（RI）明显高于良性对照组（ < 0.05），门静脉流速明显低于对照组（ < 0.05）。（2）肝细胞癌增强 CT 成像表现多为流出型增强改变，动脉期呈高或稍高密度影，增强不均匀，门静脉期和延迟期密度相对较低，增强消退。（3）肝癌患者血清 AFP 水平明显高于良性对照组（ < 0.01）。（4）彩色多普勒超声、CT 和血清 AFP 单独诊断 HCC 的灵敏度分别为 79.59%、85.71%和 66.33%，准确率分别为 83.78%、87.16%和 74.32%，三种检查联合可显著提高灵敏度至 96.94%，准确率至 93.92%，与各单项检查比较差异有统计学意义（ < 0.01）。
彩色多普勒超声和 CT 联合血清 AFP 检查可显著提高肝细胞癌诊断的灵敏度和准确率，降低误诊率，有利于早期诊断和临床早期干预。
