Goldstein I, Fontaliran F, Marie F N, Gay J
Pathol Biol (Paris). 1986 Sep;34(7):841-6.
A histopathological and histoimmunological comparison was performed on 143 fragments on coronary arteries taken from 43 patients who died of ischemic heart disease and from 20 patients who died of other diseases. The immunological study research of Ig (A, G, M) and C3 fraction of complement in the 3 coronary layers was done by the immuno-peroxidase technique. The fixation was essentially observed in fibromyocytes. A good correlation existed between atherosclerosis lesions and fixation of Ig and C3 fraction of complement in both the media and the intima. On the other hand, this correlation was not observed in the adventitia. Accumulation of immunoglobulins and of the C3 fraction of complement in atherosclerosis seemed specific and proportional to the degree of arterial well lesion. The significance and the role of this accumulation remains to be studied. It may be hypothesized that Ig and complement fixation on fibromyocyte cell receptors or on the fibrous tissue fundamental substance is followed by the formation of antigen-antibody complexes, which act as foreign bodies which are either responsible for (or a reflection) of the onset of lesions or, at least, of their increasing severity or their persistence.
对取自43例死于缺血性心脏病患者和20例死于其他疾病患者的143段冠状动脉进行了组织病理学和组织免疫学比较。采用免疫过氧化物酶技术对冠状动脉三层中的Ig（A、G、M）和补体C3成分进行免疫研究。固定主要见于纤维肌细胞。动脉粥样硬化病变与中膜和内膜中Ig及补体C3成分的固定之间存在良好的相关性。另一方面，在外膜中未观察到这种相关性。动脉粥样硬化中免疫球蛋白和补体C3成分的积累似乎具有特异性，且与动脉病变程度成正比。这种积累的意义和作用仍有待研究。可以推测，Ig和补体固定在纤维肌细胞受体或纤维组织基质上后，会形成抗原-抗体复合物，这些复合物作为异物，要么导致病变的发生（或反映病变的发生），要么至少导致病变严重程度的增加或持续存在。
