Osipov S G, Bakhov N I, Rudnev V I, Aleksandrova L Z, Eremeeva M V
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1987;10(1):11-8.
A considerable imbalance in humoral and cellular factors of immunity characterized by high B-cell activity associated with a relative T-cell deficiency has been revealed in patients with coronary heart disease. Immunological imbalance is characteristic for all the clinically pronounced forms of coronary heart disease, forming long before obvious lesions of the coronary arteries. This makes it possible to regard patients without coronarographically documented atherosclerosis as having functional form of the process pathogenetically identical to atherosclerosis according to immunological criteria.
冠心病患者体内已发现体液和细胞免疫因子存在显著失衡，其特征为B细胞活性高且伴有相对的T细胞缺乏。免疫失衡是所有临床症状明显的冠心病形式所共有的特征，早在冠状动脉出现明显病变之前就已形成。这使得在冠状动脉造影未记录到动脉粥样硬化的患者中，根据免疫学标准，有可能将其视为在发病机制上与动脉粥样硬化相同的功能性疾病形式。
