Chawla Rakesh K, Chawla Aditya K, Chaudhary Gaurav, Chopra Kamal, Chawla Madhav K
Jaipur Golden Hospital, Delhi, India.
Saroj Superspeciality Hospital, Delhi, India.
Indian J Tuberc. 2022 Apr;69(2):250-252. doi: 10.1016/j.ijtb.2021.02.013. Epub 2021 Mar 2.
To present an interesting case of unusual side effect of Mycobacterium W. in an adult COVID 19 positive male and discuss its assessment and management.
Tertiary care hospital.
One.
70 years male was admitted with complaints of fever, persistent dry cough since 10-12 days and progressive breathlessness since 3-4 days. Patient was found COVID-19 RTPCR positive and is known case of Type-II Diabetes with CAD (Post PTCA). Patient was managed conservatively with Oxygen support, I/V antibiotics, I/V Steroids, oral Favipiravir and other supportive treatment. Patient was also given injection Mycobacterium W. in dose of 0.3 ml per day intradermally at 3 different sites (both deltoids) consecutively for three days. 7-8 days after administration, patient developed bright red pustules which later got converted into small punched out ulcerations on all nine local sites of administration, which were managed conservatively with oral analgesics and local steroids for 8-10 days which healed without any scar formation.
Injection Mycobacterium W. is used in COVID 19 patients as an immunomodulator agent and has been proved to be safe in most of the cases but we encountered this unusual side effect of bright red pustules formation at all nine local sites of injection in our case most likely because of being administered subcutaneously instead of intradermally, making this an interesting case which is being reported to scientific fraternity.
呈现一例成年新冠病毒检测呈阳性男性患者出现的不寻常的结核杆菌W副作用病例,并讨论其评估与处理。
三级护理医院。
一名。
一名70岁男性因发热、持续干咳10 - 12天以及进行性呼吸困难3 - 4天入院。患者新冠病毒逆转录聚合酶链反应检测呈阳性,且为已知的II型糖尿病合并冠心病(经皮冠状动脉腔内血管成形术后)患者。患者接受了氧疗、静脉注射抗生素、静脉注射类固醇、口服法匹拉韦及其他支持性治疗。患者还连续三天在三个不同部位(双侧三角肌)每天皮内注射0.3毫升结核杆菌W。注射后7 - 8天,患者在所有九个注射部位出现鲜红色脓疱,随后转变为小的凹陷性溃疡,通过口服镇痛药和局部使用类固醇进行保守治疗8 - 10天,溃疡愈合且无瘢痕形成。
结核杆菌W注射液在新冠患者中用作免疫调节剂,在大多数情况下已被证明是安全的,但在我们的病例中,我们遇到了在所有九个注射部位出现鲜红色脓疱这一不寻常的副作用,很可能是因为采用了皮下注射而非皮内注射,使得这成为一个值得向科学界报告的有趣病例。