Department of Cell, Development & Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States.
Center for Experimental Therapeutics, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States.
Front Immunol. 2024 Oct 29;15:1450118. doi: 10.3389/fimmu.2024.1450118. eCollection 2024.
Immunomodulating agents interact with the immune system and alter the outcome of specific immune processes. As our understanding of the immune system continues to evolve, there is a growing effort to identify agents with immunomodulating applications to use therapeutically to treat various diseases. (Mw), a heat-killed mycobacterium, is an atypical mycobacterial species that possesses strong immunomodulatory properties. Mw was initially evaluated as an immune-therapeutic against leprosy, but since then Mw has generated a lot of interest and been studied for therapeutic applications across a host of diseases, such as pulmonary tuberculosis, tuberculous pericarditis, sepsis, lung cancer, and more. This article summarizes a large body of work published in the past five decades, describing various aspects of Mw and its potential for further therapeutic development.
免疫调节剂与免疫系统相互作用，改变特定免疫过程的结果。随着我们对免疫系统的理解不断发展，人们越来越努力地寻找具有免疫调节应用的药物，以便在治疗各种疾病时进行治疗。MW，一种热灭活的分枝杆菌，是一种具有很强免疫调节特性的非典型分枝杆菌。MW 最初被评估为治疗麻风病的免疫治疗药物，但自那时以来，MW 引起了很多关注，并在过去的五十年中，在许多疾病的治疗应用中进行了研究，如肺结核、结核性心包炎、败血症、肺癌等。本文总结了过去五十年发表的大量工作，描述了 MW 的各个方面及其进一步治疗开发的潜力。
