Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology Tianjin Medical University, No. 4 Gansu Road, Heping District, Tianjin, 300020, China.
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China.
Int Ophthalmol. 2022 Aug;42(8):2551-2561. doi: 10.1007/s10792-022-02303-8. Epub 2022 Apr 5.
To investigate the 5-year clinic outcomes of rigid iris-fixated pIOL on the visual performance, complications and intraocular light scattering in northern Chinese.
Thirty eyes implanted with iris-fixated phakic IOLs (pIOLs group) and 34 eyes with high myopia (myopia group) were involved in this study. At preoperatively, 6 months, 1, 3, and 5 years postoperatively, the uncorrected visual acuity (UCVA), best-spectacle corrected visual acuity (BSCVA), endothelial cell density (ECD), and intraocular pressure (IOP) were measured in pIOLs group. The objective scatter index (OSI), modulation transfer function cut off (MTF cut off), and Strehl ratio were measured by Optical Quality Analysis System and a pseudophakic dysphotopsia questionnaire (PDQ) was used to evaluate the subjects' satisfaction in pIOLs and myopia groups.
At 5 years postoperatively, an UCVA of 20/20 or better was found in 43.33% of eyes in pIOLs group. At 6 months, 1, 3, and 5 years postoperatively, the mean ECD decrease were 1.29% ± 0.45%, 2.59% ± 1.30%, 6.67% ± 2.26%, and 10.80% ± 3.48%. The value of OSI in pIOLs group was significantly higher than that in myopia group (P < 0.001). The PDQ results showed that the subjects in myopia group complained less with intolerance of bright lights than those in pIOLs group. The values of Strehl ratio and MTF cut off in pIOLs group were significantly lower than that in myopia group (P < 0.001).
Iris-fixated pIOL induce more intraocular light scattering. A significant decrease in ECD was observed at 5 years postoperatively. An annual evaluation of ECD is necessary for patients undergoing pIOL implantation.
研究北方中国人硬性虹膜固定型后房型有晶状体眼人工晶状体（pIOL）在视觉性能、并发症和眼内光散射方面的 5 年临床结果。
本研究纳入 30 只眼植入虹膜固定型有晶状体眼人工晶状体（pIOL 组）和 34 只眼高度近视（近视组）。在术前、术后 6 个月、1 年、3 年和 5 年，测量 pIOL 组的未矫正视力（UCVA）、最佳矫正视力（BSCVA）、内皮细胞密度（ECD）和眼内压（IOP）。使用光学质量分析系统测量客观散射指数（OSI）、调制传递函数截止值（MTF cutoff）和斯特列尔比，使用无晶状体眼视觉不良问卷（PDQ）评估 pIOL 组和近视组患者的满意度。
术后 5 年，pIOL 组有 43.33%的眼视力达到 20/20 或更好。术后 6 个月、1 年、3 年和 5 年，平均 ECD 下降分别为 1.29%±0.45%、2.59%±1.30%、6.67%±2.26%和 10.80%±3.48%。pIOL 组的 OSI 值明显高于近视组（P<0.001）。PDQ 结果显示，近视组患者对光敏感不耐受的抱怨少于 pIOL 组。pIOL 组的斯特列尔比和 MTF cutoff 值明显低于近视组（P<0.001）。
硬性虹膜固定型 pIOL 引起更多的眼内光散射。术后 5 年观察到 ECD 显著下降。pIOL 植入患者需要每年评估 ECD。
