男性和女性在体育活动对大脑完整性的影响方面表现出部分不同的效应。
Men and women show partly distinct effects of physical activity on brain integrity.
作者信息
Gonneaud Julie, Moreau Ilana, Felisatti Francesca, Arenaza-Urquijo Eider, Ourry Valentin, Touron Edelweiss, de la Sayette Vincent, Vivien Denis, Chételat Gaël
机构信息
Normandie Université Université de Caen Institut National de la Santé et de la Recherche Médicale Unité 1237 "Physiopathology and Imaging of Neurological Disorders," Institut Blood and Brain@ Caen-Normandie GIP Cyceron Caen France.
Barcelonabeta Brain Research Center Fundación Pasqual Maragall Barcelona Spain.
出版信息
Alzheimers Dement (Amst). 2022 Mar 28;14(1):e12302. doi: 10.1002/dad2.12302. eCollection 2022.
INTRODUCTION
Physical inactivity and female sex are independently associated with increased Alzheimer's disease (AD) lifetime risk. This study investigates the possible interactions between sex and physical activity on neuroimaging biomarkers.
METHODS
In 134 cognitively unimpaired older adults (≥65 years, 82 women) from the Age-Well randomized controlled trial (baseline data), we investigated the association between physical activity and multimodal neuroimaging (gray matter volume, glucose metabolism, perfusion, and amyloid burden), and how sex modulates these associations.
RESULTS
The anterior cingulate cortex volume was independently associated with sex and physical activity. Sex and physical activity interacted on perfusion and amyloid deposition in medial parietal regions, such that physical activity was related to perfusion only in women, and to amyloid burden only in men.
DISCUSSION
Physical activity has both sex-dependent and sex-independent associations with brain integrity. Our findings highlight partly distinct reserve mechanisms in men and women, which might in turn influence their risk of AD.
HIGHLIGHTS
Sex and physical activity have been linked to Alzheimer's disease (AD) progression.The association of sex and physical activity with brain health is partly independent.Different reserve mechanisms exist in men and women.
引言
缺乏身体活动和女性性别分别与阿尔茨海默病（AD）终生风险增加相关。本研究调查了性别与身体活动在神经影像生物标志物方面可能存在的相互作用。
方法
在来自“健康老龄化”随机对照试验（基线数据）的134名认知未受损的老年人（≥65岁，82名女性）中，我们研究了身体活动与多模态神经影像（灰质体积、葡萄糖代谢、灌注和淀粉样蛋白负荷）之间的关联，以及性别如何调节这些关联。
结果
前扣带回皮质体积与性别和身体活动独立相关。性别和身体活动在内侧顶叶区域的灌注和淀粉样蛋白沉积方面存在相互作用，即身体活动仅与女性的灌注相关，仅与男性的淀粉样蛋白负荷相关。
讨论
身体活动与大脑完整性存在性别依赖性和非性别依赖性关联。我们的研究结果凸显了男性和女性部分不同的储备机制，这反过来可能会影响他们患AD的风险。
要点
性别和身体活动与阿尔茨海默病（AD）进展有关。性别和身体活动与大脑健康的关联部分是独立的。男性和女性存在不同的储备机制。
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